TY - JOUR
T1 - 5-HT(1A) receptor-mediated inhibition of long-term potentiation in rat visual cortex
AU - Edagawa, Yoshikuni
AU - Saito, Hiroshi
AU - Abe, Kazuho
PY - 1998/5/22
Y1 - 1998/5/22
N2 - We investigated the effect of 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT), a 5-HT(1A) receptor agonist, on the induction of long-term potentiation in rat visual cortex slices. Perfusion of 8-OH-DPAT (0.1-10 μM) did not affect layer II/III field potentials evoked by test stimulation of layer IV, but significantly reduced long-term potentiation induced by tetanic stimulation. The inhibitory effect of 8-OH-DPAT was blocked by the 5-HT1 receptor antagonist, pindolol (10 μM), but not by the 5-HT2,7 receptor antagonist, ritanserin (100 μM), nor by the 5-HT3,4 receptor antagonist, MDL72222 (100 μM). These results suggest that the rat visual cortex long-term potentiation is inhibited by 5-HT(1A) receptor stimulation.
AB - We investigated the effect of 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT), a 5-HT(1A) receptor agonist, on the induction of long-term potentiation in rat visual cortex slices. Perfusion of 8-OH-DPAT (0.1-10 μM) did not affect layer II/III field potentials evoked by test stimulation of layer IV, but significantly reduced long-term potentiation induced by tetanic stimulation. The inhibitory effect of 8-OH-DPAT was blocked by the 5-HT1 receptor antagonist, pindolol (10 μM), but not by the 5-HT2,7 receptor antagonist, ritanserin (100 μM), nor by the 5-HT3,4 receptor antagonist, MDL72222 (100 μM). These results suggest that the rat visual cortex long-term potentiation is inhibited by 5-HT(1A) receptor stimulation.
KW - 5-HT (5-hydroxytryptamine, serotonin)
KW - 5-HT(1A) receptor
KW - 8-OH-DPAT (8-hydroxy-2-(N,N-dipropylamino)tetralin
KW - Field potential
KW - Long-term potentiation
KW - Visual cortex
UR - http://www.scopus.com/inward/record.url?scp=0032557242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032557242&partnerID=8YFLogxK
U2 - 10.1016/S0014-2999(98)00286-6
DO - 10.1016/S0014-2999(98)00286-6
M3 - Article
C2 - 9671101
AN - SCOPUS:0032557242
SN - 0014-2999
VL - 349
SP - 221
EP - 224
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -