A convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins using the trimethylsilyl chloride-dimethyl sulfoxide-trifluoroacetic acid system

Hirokazu Tamamura; Tsunehito Ishihara; Akira Otaka; Takaki Koide; Kengo Miyoshi; Toshiro Ibuka; Nobutaka Fujii

doi:10.1039/P19960001911

A convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins using the trimethylsilyl chloride-dimethyl sulfoxide-trifluoroacetic acid system

Hirokazu Tamamura, Tsunehito Ishihara, Akira Otaka, Takaki Koide, Kengo Miyoshi, Toshiro Ibuka, Nobutaka Fujii^*

^*この研究の対応する著者

研究成果: Article › 査読

5 被引用数 (Scopus)

抄録

Cystine-containing peptides are obtained in a one-pot manner by treatment of protected peptidyl resins with trimethylsilyl chloride (TMSCl)-dimethyl sulfoxide (DMSO)-trifluoroacetic acid (TFA). The TMSCl-DMSO-TFA system simultaneously cleaves peptides from the resins, with deprotection of all side chain protecting groups and disulfide bond formation.

本文言語	English
ページ（範囲）	1911-1912
ページ数	2
ジャーナル	Journal of the Chemical Society - Perkin Transactions 1
号	16
DOI	https://doi.org/10.1039/P19960001911
出版ステータス	Published - 1996 8月 21
外部発表	はい

ASJC Scopus subject areas

化学 (全般)

文献へのアクセス

10.1039/P19960001911

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引用スタイル

Tamamura, H., Ishihara, T., Otaka, A., Koide, T., Miyoshi, K., Ibuka, T., & Fujii, N. (1996). A convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins using the trimethylsilyl chloride-dimethyl sulfoxide-trifluoroacetic acid system. Journal of the Chemical Society - Perkin Transactions 1, (16), 1911-1912. https://doi.org/10.1039/P19960001911

Tamamura, H, Ishihara, T, Otaka, A, Koide, T, Miyoshi, K, Ibuka, T & Fujii, N 1996, 'A convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins using the trimethylsilyl chloride-dimethyl sulfoxide-trifluoroacetic acid system', Journal of the Chemical Society - Perkin Transactions 1, no. 16, pp. 1911-1912. https://doi.org/10.1039/P19960001911

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