A Coupled FEM-SPH Modeling Technique to Investigate the Contractility of Biohybrid Thin Films

Lorenzo Vannozzi, Tommaso Mazzocchi, Arihiro Hasebe, Shinji Takeoka, Toshinori Fujie*, Leonardo Ricotti


研究成果: Article査読

4 被引用数 (Scopus)


Biohybrid actuators have the potential to overcome the limitations of traditional actuators employed in robotics, thanks to the unique features of living contractile muscle cells, which can be used to power artificial elements. This paper describes a computational approach for the estimation of the contractile capabilities of skeletal muscle cell-powered biohybrid actuators based on polymeric thin films. The proposed model grounds on the coupling between finite element modeling and smooth particle hydrodynamics. This allows describing the overall condition, including the viscous forces caused by the surrounding liquid medium, in which biohybrid systems are normally immersed. The model is calibrated by analyzing the contractile behavior of polydimethylsiloxane films coupled with skeletal muscle cells, reported in the literature as muscular thin films. Afterward, it is applied to poly (D, L-lactic acid) thin films to explore the behavior of these systems, due to myotubes cultured on them, evaluating the role of thickness, tissue maturation status, and hydrostatic pressure on the contractile performance. These results pave the way toward a novel optimization approach of biohybrid robot design relying on the simulation of all the boundary conditions, thus reducing the need for extensive trial-and-error efforts.

ジャーナルAdvanced Biosystems
出版ステータスPublished - 2020 8月 1

ASJC Scopus subject areas

  • 生体材料
  • 生体医工学
  • 生化学、遺伝学、分子生物学(全般)


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