抄録
A highly stereoselective intramolecular Diels-Alder (IMDA) reaction for the construction of the AB ring moiety of bruceantin is described. The product of the IMDA reaction comprises a trans-AB ring junction and stereotetrad including an all carbon quaternary stereogenic center, wherein three stereogenic centers correspond to those of bruceantin. Functional groups embedded in the product are suitable for a variety of transformations. Hence, this IMDA product could be a useful intermediate for the enantioselective total synthesis of not only bruceantin, but also other bioactive compounds.
本文言語 | English |
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ページ(範囲) | 1247-1251 |
ページ数 | 5 |
ジャーナル | Tetrahedron Letters |
巻 | 56 |
号 | 10 |
DOI | |
出版ステータス | Published - 2015 3月 4 |
ASJC Scopus subject areas
- 生化学
- 創薬
- 有機化学