A Mathematical Modeling and Treatment Analysis of Dynamic Glucose Metabolism with Brain-based Regulatory Mechanism

Hanae Ofuji; Yasuaki Wasa; Kenji Hirata; Hidenori Kimura; Kenko Uchida

doi:10.1016/j.ifacol.2023.10.1525

A Mathematical Modeling and Treatment Analysis of Dynamic Glucose Metabolism with Brain-based Regulatory Mechanism

Hanae Ofuji^*, Yasuaki Wasa^*, Kenji Hirata, Hidenori Kimura, Kenko Uchida^*

^*この研究の対応する著者

先進理工学部

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

This paper presents an elaborate mathematical model of dynamic glucose metabolism. Although it is known that the control mechanism of glucose metabolism is partly related to the brain, almost all existing papers ignore the brain mechanism in the dynamic glucose metabolism of diabetes. Then, we propose a refined mathematical model to integrate the brain-based regulatory mechanism with leptin into the conventional FDA approval model for all human beings to obtain an optimal combined treatment of not only insulin therapy but also leptin therapy. The effectiveness and limitations of the proposed combined therapy with insulin and leptin for not only type 1 diabetes mellitus but also type 2 diabetes mellitus are also evaluated through in silico experiments.

本文言語	English
ホスト出版物のタイトル	IFAC-PapersOnLine
編集者	Hideaki Ishii, Yoshio Ebihara, Jun-ichi Imura, Masaki Yamakita
出版社	Elsevier B.V.
ページ	3630-3635
ページ数	6
版	2
ISBN（電子版）	9781713872344
DOI	https://doi.org/10.1016/j.ifacol.2023.10.1525
出版ステータス	Published - 2023 7月 1
イベント	22nd IFAC World Congress - Yokohama, Japan 継続期間: 2023 7月 9 → 2023 7月 14

出版物シリーズ

名前	IFAC-PapersOnLine
番号	2
巻	56
ISSN（電子版）	2405-8963

Conference

Conference	22nd IFAC World Congress
国/地域	Japan
City	Yokohama
Period	23/7/9 → 23/7/14

ASJC Scopus subject areas

制御およびシステム工学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1016/j.ifacol.2023.10.1525

他のファイルとリンク

引用スタイル

Ofuji, H., Wasa, Y., Hirata, K., Kimura, H., & Uchida, K. (2023). A Mathematical Modeling and Treatment Analysis of Dynamic Glucose Metabolism with Brain-based Regulatory Mechanism. In H. Ishii, Y. Ebihara, J. Imura, & M. Yamakita (Eds.), IFAC-PapersOnLine (2 ed., pp. 3630-3635). (IFAC-PapersOnLine; Vol. 56, No. 2). Elsevier B.V.. https://doi.org/10.1016/j.ifacol.2023.10.1525

A Mathematical Modeling and Treatment Analysis of Dynamic Glucose Metabolism with Brain-based Regulatory Mechanism. / Ofuji, Hanae; Wasa, Yasuaki; Hirata, Kenji その他.
IFAC-PapersOnLine. ed. / Hideaki Ishii; Yoshio Ebihara; Jun-ichi Imura; Masaki Yamakita. 2. ed. Elsevier B.V., 2023. p. 3630-3635 (IFAC-PapersOnLine; Vol. 56, No. 2).

研究成果: Conference contribution

Ofuji, H, Wasa, Y, Hirata, K, Kimura, H & Uchida, K 2023, A Mathematical Modeling and Treatment Analysis of Dynamic Glucose Metabolism with Brain-based Regulatory Mechanism. in H Ishii, Y Ebihara, J Imura & M Yamakita (eds), IFAC-PapersOnLine. 2 edn, IFAC-PapersOnLine, no. 2, vol. 56, Elsevier B.V., pp. 3630-3635, 22nd IFAC World Congress, Yokohama, Japan, 23/7/9. https://doi.org/10.1016/j.ifacol.2023.10.1525

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A Mathematical Modeling and Treatment Analysis of Dynamic Glucose Metabolism with Brain-based Regulatory Mechanism

抄録

出版物シリーズ

Conference

ASJC Scopus subject areas

UN SDG

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