TY - JOUR
T1 - A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa
AU - Yamashita, Takahiro
AU - Nakao, Yoichi
AU - Matsunaga, Shigeki
AU - Oikawa, Tsutomu
AU - Imahara, Yukimitsu
AU - Fusetani, Nobuhiro
N1 - Funding Information:
We are indebted to the crew of R/V Toyoshio-maru of Hiroshima University for assistance in collection of the samples. This work was partly supported by Waseda University Grant for Special Research Projects, Nissui Research foundation, and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (#19310138).
PY - 2009/3/15
Y1 - 2009/3/15
N2 - A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-HTPE inhibited tube formation of EA.hy926 cells at the concentration of 20-40 μM.
AB - A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-HTPE inhibited tube formation of EA.hy926 cells at the concentration of 20-40 μM.
KW - Angiogenesis inhibitor
KW - Marine natural products
KW - Oxylipin
KW - Tube formation
UR - http://www.scopus.com/inward/record.url?scp=62149148140&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62149148140&partnerID=8YFLogxK
U2 - 10.1016/j.bmc.2008.10.083
DO - 10.1016/j.bmc.2008.10.083
M3 - Article
C2 - 19036594
AN - SCOPUS:62149148140
SN - 0968-0896
VL - 17
SP - 2181
EP - 2184
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 6
ER -