@article{caafa3648f88491eb2408ae468762643,
title = "A new peptaibol, RK-026A, from the soil fungus Trichoderma sp. RK10-F026 by culture condition-dependent screening",
abstract = "A new peptaibol, RK-026A (1) was isolated from a fungus, Trichoderma sp. RK10-F026, along with atroviridin B (2), alamethicin II (3), and polysporin B (4) as a cytotoxic compound, which was selected by principal component analysis of the MS data from 5 different culture conditions. The structure of 1 was determined as a new atroviridin B derivative containing Glu at the 18th residue instead of Gln by NMR and HR-MS analyses including the investigation of detailed MS/MS fragmentations. 1 showed cytotoxicity toward K562 leukemia cells at an IC50 value of 4.1 mm.",
keywords = "K562, cytotoxicity, fungi, natural product, peptaibols",
author = "Rawa, {Mira Syahfriena Amir} and Toshihiko Nogawa and Akiko Okano and Yushi Futamura and Takemichi Nakamura and Wahab, {Habibah A.} and Hiroyuki Osada",
note = "Funding Information: This work was supported in part by JSPS KAKENHI under Grant [numbers JP17H06412 and JP20K05858]. Publisher Copyright: {\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.",
year = "2021",
month = jan,
day = "1",
doi = "10.1093/bbb/zbaa051",
language = "English",
volume = "85",
pages = "69--76",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "1",
}