TY - JOUR
T1 - A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex
AU - Remedios, Ryan
AU - Huilgol, Dhananjay
AU - Saha, Bhaskar
AU - Hari, Padmanabhan
AU - Bhatnagar, Lahar
AU - Kowalczyk, Thomas
AU - Hevner, Robert F.
AU - Suda, Yoko
AU - Aizawa, Shinichi
AU - Ohshima, Toshio
AU - Stoykova, Anastassia
AU - Tole, Shubha
N1 - Funding Information:
We thank R. Kageyama, Y. Nakagawa, F. D. Porter, T. Rabbitts, C. Ragsdale, E. Grove and Y. Zhao for gifts of plasmid DNA; F. D. Porter for the Lhx2 mutant breeding pairs; M. Frotscher for the gift of reeler mutant tissue for preliminary experiments; and V. Vaidya, M. Benekareddy and A. Nair for critical comments on the manuscript. The Rat-401 monoclonal antibody to Nestin, developed by S. Hockfield, was obtained from the Developmental Studies Hybridoma Bank and was developed under the auspices of the US National Institute of Child Health and Human Development and maintained by The University of Iowa. We also thank the Tata Institute of Fundamental Research Animal House staff for excellent support. This work was supported by a Wellcome Trust Senior Fellowship (056684/ Z/99/Z) and a Swarnajayanti Fellowship (Dept. of Science and Technology, Govt. of India) to S.T. and a Kanwal Rekhi Career Development Award (Tata Institute of Fundamental Research Endowment Fund) to B.S. and P.H.
PY - 2007/9
Y1 - 2007/9
N2 - The amygdaloid complex consists of diverse nuclei that belong to distinct functional systems, yet many issues about its development are poorly understood. Here, we identify a stream of migrating cells that form specific amygdaloid nuclei in mice. In utero electroporation showed that this caudal amygdaloid stream (CAS) originated in a unique domain at the caudal telencephalic pole that is contiguous with the dorsal pallium, which was previously thought to generate only neocortical cells. The CAS and the neocortex share mechanisms for specification (transcription factors Tbr1, Lhx2 and Emx1/2) and migration (reelin and Cdk5). Reelin, a critical cue for migration in the neocortex, and Cdk5, which is specifically required for migration along radial glia in the neocortex, were both selectively required for the normal migration of the CAS, but not for that of other amygdaloid nuclei. This is first evidence of a dorsal pallial contribution to the amygdala, demonstrating a developmental and mechanistic link between the amygdala and the neocortex.
AB - The amygdaloid complex consists of diverse nuclei that belong to distinct functional systems, yet many issues about its development are poorly understood. Here, we identify a stream of migrating cells that form specific amygdaloid nuclei in mice. In utero electroporation showed that this caudal amygdaloid stream (CAS) originated in a unique domain at the caudal telencephalic pole that is contiguous with the dorsal pallium, which was previously thought to generate only neocortical cells. The CAS and the neocortex share mechanisms for specification (transcription factors Tbr1, Lhx2 and Emx1/2) and migration (reelin and Cdk5). Reelin, a critical cue for migration in the neocortex, and Cdk5, which is specifically required for migration along radial glia in the neocortex, were both selectively required for the normal migration of the CAS, but not for that of other amygdaloid nuclei. This is first evidence of a dorsal pallial contribution to the amygdala, demonstrating a developmental and mechanistic link between the amygdala and the neocortex.
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U2 - 10.1038/nn1955
DO - 10.1038/nn1955
M3 - Article
C2 - 17694053
AN - SCOPUS:34548314071
SN - 1097-6256
VL - 10
SP - 1141
EP - 1150
JO - Nature Neuroscience
JF - Nature Neuroscience
IS - 9
ER -