A study of magnetic drug delivery system using bulk high temperature superconducting magnet

Shigehiro Nishijima; Shin Ichi Takeda; Fumihito Mishima; Yasuhiko Tabata; Masaya Yamamoto; Jun Ichiro Joh; Hiroshi Iseki; Yoshihiro Muragaki; Akira Sasaki; Jun Kubota; Norihide Saho

doi:10.1109/TASC.2008.921967

A study of magnetic drug delivery system using bulk high temperature superconducting magnet

Shigehiro Nishijima^*, Shin Ichi Takeda, Fumihito Mishima, Yasuhiko Tabata, Masaya Yamamoto, Jun Ichiro Joh, Hiroshi Iseki, Yoshihiro Muragaki, Akira Sasaki, Jun Kubota, Norihide Saho

^*この研究の対応する著者

研究成果: Article › 査読

38 被引用数 (Scopus)

抄録

A magnetic drug delivery system (MDDS) has been studied to navigate and/or accumulate the magnetic seeded drug at a local diseased part in the human body. The bulk high temperature superconductors (HTS) are employed to control the drug because they would produce the required magnetic fields for MDDS. The trajectory of the ferromagnetic particles in the blood vessel was calculated and the possibility of the navigation of the drug is discussed. In the experiment the HTS (GdBaCuO) which produces the magnetic field of 4.5 T at the surface, was located 25 mm apart from the Y-shaped blood vessel. The drug navigation probability to the desired direction was confirmed to be higher than 80%. A rat experiment was also performed successfully using a permanent magnet. The possible MDDS system will be discussed.

本文言語	English
論文番号	4517321
ページ（範囲）	874-877
ページ数	4
ジャーナル	IEEE Transactions on Applied Superconductivity
巻	18
号	2
DOI	https://doi.org/10.1109/TASC.2008.921967
出版ステータス	Published - 2008 6月
外部発表	はい

ASJC Scopus subject areas

電子材料、光学材料、および磁性材料
凝縮系物理学
電子工学および電気工学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1109/TASC.2008.921967

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title = "A study of magnetic drug delivery system using bulk high temperature superconducting magnet",

abstract = "A magnetic drug delivery system (MDDS) has been studied to navigate and/or accumulate the magnetic seeded drug at a local diseased part in the human body. The bulk high temperature superconductors (HTS) are employed to control the drug because they would produce the required magnetic fields for MDDS. The trajectory of the ferromagnetic particles in the blood vessel was calculated and the possibility of the navigation of the drug is discussed. In the experiment the HTS (GdBaCuO) which produces the magnetic field of 4.5 T at the surface, was located 25 mm apart from the Y-shaped blood vessel. The drug navigation probability to the desired direction was confirmed to be higher than 80%. A rat experiment was also performed successfully using a permanent magnet. The possible MDDS system will be discussed.",

keywords = "Bulk high temperature superconductor, Magnetic drug delivery system, Magnetic seeded drug, Nano-sized particle, Navigation of drag",

author = "Shigehiro Nishijima and Takeda, {Shin Ichi} and Fumihito Mishima and Yasuhiko Tabata and Masaya Yamamoto and Joh, {Jun Ichiro} and Hiroshi Iseki and Yoshihiro Muragaki and Akira Sasaki and Jun Kubota and Norihide Saho",

note = "Funding Information: Manuscript received August 25, 2007. This work was supported in part by NEDO under R/D Project on Next-Generation DDS Treatment Systems for Malignant Tumors, R/D on Next-Generation DDS Treatment Systems for Deep Therapy.",

year = "2008",

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doi = "10.1109/TASC.2008.921967",

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AU - Nishijima, Shigehiro

AU - Takeda, Shin Ichi

AU - Mishima, Fumihito

AU - Tabata, Yasuhiko

AU - Yamamoto, Masaya

AU - Joh, Jun Ichiro

AU - Iseki, Hiroshi

AU - Muragaki, Yoshihiro

AU - Sasaki, Akira

AU - Kubota, Jun

AU - Saho, Norihide

N1 - Funding Information: Manuscript received August 25, 2007. This work was supported in part by NEDO under R/D Project on Next-Generation DDS Treatment Systems for Malignant Tumors, R/D on Next-Generation DDS Treatment Systems for Deep Therapy.

PY - 2008/6

Y1 - 2008/6

N2 - A magnetic drug delivery system (MDDS) has been studied to navigate and/or accumulate the magnetic seeded drug at a local diseased part in the human body. The bulk high temperature superconductors (HTS) are employed to control the drug because they would produce the required magnetic fields for MDDS. The trajectory of the ferromagnetic particles in the blood vessel was calculated and the possibility of the navigation of the drug is discussed. In the experiment the HTS (GdBaCuO) which produces the magnetic field of 4.5 T at the surface, was located 25 mm apart from the Y-shaped blood vessel. The drug navigation probability to the desired direction was confirmed to be higher than 80%. A rat experiment was also performed successfully using a permanent magnet. The possible MDDS system will be discussed.

AB - A magnetic drug delivery system (MDDS) has been studied to navigate and/or accumulate the magnetic seeded drug at a local diseased part in the human body. The bulk high temperature superconductors (HTS) are employed to control the drug because they would produce the required magnetic fields for MDDS. The trajectory of the ferromagnetic particles in the blood vessel was calculated and the possibility of the navigation of the drug is discussed. In the experiment the HTS (GdBaCuO) which produces the magnetic field of 4.5 T at the surface, was located 25 mm apart from the Y-shaped blood vessel. The drug navigation probability to the desired direction was confirmed to be higher than 80%. A rat experiment was also performed successfully using a permanent magnet. The possible MDDS system will be discussed.

KW - Bulk high temperature superconductor

KW - Magnetic drug delivery system

KW - Magnetic seeded drug

KW - Nano-sized particle

KW - Navigation of drag

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A study of magnetic drug delivery system using bulk high temperature superconducting magnet

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ASJC Scopus subject areas

UN SDG

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