Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator

Yukiko Umeda; Kazuo Furihata; Shohei Sakuda; Hiromichi Nagasawa; Ken Ishigami; Hidenori Watanabe; Miho Izumikawa; Motoki Takagi; Takayuki Doi; Yoichi Nakao; Kazuo Shin-ya

doi:10.1021/ol7017856

Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator

Yukiko Umeda, Kazuo Furihata, Shohei Sakuda, Hiromichi Nagasawa, Ken Ishigami, Hidenori Watanabe, Miho Izumikawa, Motoki Takagi, Takayuki Doi, Yoichi Nakao, Kazuo Shin-ya^*

^*この研究の対応する著者

先進理工学部

研究成果: Article › 査読

27 被引用数 (Scopus)

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In the course of our screening program for regulators of a molecular chaperone GRP78 expression, we isolated a novel inhibitor of GRP78 expression, designated as prunustatin A, from Streptomyces violaceoniger 4521-SVS3. The planar structure of prunustatin A was determined to be an oxidized type of the neoantimycin family. Its absolute stereochemistry was established to be 2R, 4S, 6S, 7R, 9S, and 29S by analyzing chemically degraded components obtained from the derivative of prunustatin A.

本文言語	English
ページ（範囲）	4239-4242
ページ数	4
ジャーナル	Organic Letters
巻	9
号	21
DOI	https://doi.org/10.1021/ol7017856
出版ステータス	Published - 2007 10月 11

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1021/ol7017856

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T1 - Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator

AU - Umeda, Yukiko

AU - Furihata, Kazuo

AU - Sakuda, Shohei

AU - Nagasawa, Hiromichi

AU - Ishigami, Ken

AU - Watanabe, Hidenori

AU - Izumikawa, Miho

AU - Takagi, Motoki

AU - Doi, Takayuki

AU - Nakao, Yoichi

AU - Shin-ya, Kazuo

PY - 2007/10/11

Y1 - 2007/10/11

N2 - In the course of our screening program for regulators of a molecular chaperone GRP78 expression, we isolated a novel inhibitor of GRP78 expression, designated as prunustatin A, from Streptomyces violaceoniger 4521-SVS3. The planar structure of prunustatin A was determined to be an oxidized type of the neoantimycin family. Its absolute stereochemistry was established to be 2R, 4S, 6S, 7R, 9S, and 29S by analyzing chemically degraded components obtained from the derivative of prunustatin A.

AB - In the course of our screening program for regulators of a molecular chaperone GRP78 expression, we isolated a novel inhibitor of GRP78 expression, designated as prunustatin A, from Streptomyces violaceoniger 4521-SVS3. The planar structure of prunustatin A was determined to be an oxidized type of the neoantimycin family. Its absolute stereochemistry was established to be 2R, 4S, 6S, 7R, 9S, and 29S by analyzing chemically degraded components obtained from the derivative of prunustatin A.

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JO - Organic Letters

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Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator

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