Acquirement of hairpin ribozyme activity by the long substrate-binding site.

S. Hisamatsu; S. Sonoki; Yo Kikuchi

Acquirement of hairpin ribozyme activity by the long substrate-binding site.

S. Hisamatsu^*, S. Sonoki, Yo Kikuchi

^*この研究の対応する著者

研究成果: Article › 査読

抄録

Three hairpin ribozymes were designed to cleave Escherichia coli beta-glucuronidase (GUS) mRNA at a target site. Two of the designed ribozymes (HG10L and HG10L2) had long substrate binding sites and the other (HG10) had short substrate binding site. All three ribozymes cleaved the substrate, and HG10L and HG10L2 cleaved it efficiently. However, HG10 had very low activity. Effect of length of substrate binding site of the ribozyme will be discussed.

本文言語	English
ページ（範囲）	173-174
ページ数	2
ジャーナル	Nucleic acids symposium series
号	29
出版ステータス	Published - 1993
外部発表	はい

ASJC Scopus subject areas

医学（全般）

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引用スタイル

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Acquirement of hairpin ribozyme activity by the long substrate-binding site.

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