TY - JOUR
T1 - Age-dependent atypicalities in body- and face-sensitive activation of the EBA and FFA in individuals with ASD
AU - Okamoto, Yuko
AU - Kosaka, Hirotaka
AU - Kitada, Ryo
AU - Seki, Ayumi
AU - Tanabe, Hiroki C.
AU - Hayashi, Masamichi J.
AU - Kochiyama, Takanori
AU - Saito, Daisuke N.
AU - Yanaka, Hisakazu T.
AU - Munesue, Toshio
AU - Ishitobi, Makoto
AU - Omori, Masao
AU - Wada, Yuji
AU - Okazawa, Hidehiko
AU - Koeda, Tatsuya
AU - Sadato, Norihiro
N1 - Funding Information:
We thank S. Tomita for the helping in collecting the data. This work was partly supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science to N. Sadato (21220005, 15H01846), T. Munesue (21591509), H. Kosaka (15K08093), and R. Kitada (25871059). Part of this study was from the results of the following projects, which were carried out under the Strategic Research Program for Brain Sciences from MEXT and AMED: “Development of biomarker candidates for social behavior” and “Integrated research on neuropsychiatric disorders”. H. Kosaka was supported by the Takeda Science Foundation, and M. J. Hayashi was supported by JSPS Research Fellowships for Young Scientists.
Publisher Copyright:
© 2017 Elsevier Ireland Ltd and Japan Neuroscience Society
PY - 2017/6
Y1 - 2017/6
N2 - Individuals with autism spectrum disorder (ASD) have difficuly in recognizing bodies and faces, which are more pronounced in children than adults. If such difficulties originate from dysfunction of the extrastriate body area (EBA) and the fusiform face area (FFA), activation in these regions might be more atypical in children than in adults. We preformed functional magnetic resonance imaging while children and adults with ASD and age-matched typically developed (TD) individuals observed face, body, car, and scene. To examine various aspects, we performed individual region of interest (ROI) analysis, as well as conventional random effect group analysis. At individual ROI analysis, we examined the ratio of participants showing a category-sensitive response, the size of regions, location and activation patterns among the four object categories. Adults with ASD showed no atypicalities in activation of the EBA and FFA, whereas children with ASD showed atypical activation in these regions. Specifically, a smaller percentage of children with ASD showed face-sensitive activation of the FFA than TD children. Moreover, the size of the EBA was smaller in children with ASD than in TD children. Our results revealed atypicalities in both the FFA and EBA in children with ASD but not in adults with ASD.
AB - Individuals with autism spectrum disorder (ASD) have difficuly in recognizing bodies and faces, which are more pronounced in children than adults. If such difficulties originate from dysfunction of the extrastriate body area (EBA) and the fusiform face area (FFA), activation in these regions might be more atypical in children than in adults. We preformed functional magnetic resonance imaging while children and adults with ASD and age-matched typically developed (TD) individuals observed face, body, car, and scene. To examine various aspects, we performed individual region of interest (ROI) analysis, as well as conventional random effect group analysis. At individual ROI analysis, we examined the ratio of participants showing a category-sensitive response, the size of regions, location and activation patterns among the four object categories. Adults with ASD showed no atypicalities in activation of the EBA and FFA, whereas children with ASD showed atypical activation in these regions. Specifically, a smaller percentage of children with ASD showed face-sensitive activation of the FFA than TD children. Moreover, the size of the EBA was smaller in children with ASD than in TD children. Our results revealed atypicalities in both the FFA and EBA in children with ASD but not in adults with ASD.
KW - Autism spectrum disorders
KW - Development
KW - Extrastriate body area
KW - Fmri
KW - Fusiform face area
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U2 - 10.1016/j.neures.2017.02.001
DO - 10.1016/j.neures.2017.02.001
M3 - Article
C2 - 28193532
AN - SCOPUS:85013741784
SN - 0168-0102
VL - 119
SP - 38
EP - 52
JO - Neuroscience Research
JF - Neuroscience Research
ER -