Age modifies the association of dietary protein intake with All-cause mortality in patients with chronic kidney disease

Daiki Watanabe, Shinji Machida, Naoki Matsumoto, Yugo Shibagaki, Tsutomu Sakurada*

*この研究の対応する著者

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Whether the effect of a low-protein diet on progression to end-stage renal disease (ESRD) and mortality risk differs between young and elderly adults with chronic kidney disease (CKD) is unclear. We conducted a retrospective CKD cohort study to investigate the association between protein intake and mortality or renal outcomes and whether age affects this association. The cohort comprised 352 patients with stage G3-5 CKD who had been followed up for a median 4.2 years, had undergone educational hospitalization, and for whom baseline protein intake was estimated from 24-h urine samples. We classified the patients into a very low protein intake (VLPI) group (<0.6 g/kg ideal body weight/day), a low protein intake (LPI) group (0.6–0.8 g), and a moderate protein intake (MPI) group (>0.8 g). Compared with the LPI group, the MPI group had a significantly lower risk of all-cause mortality (hazard ratio: 0.29; 95% confidence interval: 0.07 to 0.94) but a similar risk of ESRD, although relatively high protein intake was related to a faster decline in the estimated glomerular filtration rate. When examined per age group, these results were observed only among the elderly patients, suggesting that the association between baseline dietary protein intake and all-cause mortality in patients with CKD is age-dependent.

本文言語English
論文番号1744
ジャーナルNutrients
10
11
DOI
出版ステータスPublished - 2018 11月 13
外部発表はい

ASJC Scopus subject areas

  • 食品科学
  • 栄養および糖尿病

フィンガープリント

「Age modifies the association of dietary protein intake with All-cause mortality in patients with chronic kidney disease」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル