TY - JOUR
T1 - Aldsulfin, a novel unusual anti-mannheimiosis epithiodiketopiperazine antibiotic produced by Lasiodiplodia pseudotheobromae FKI-4499
AU - Sakai, Kazunari
AU - Iwatsuki, Masato
AU - Iizuka, Masato
AU - Asami, Yukihiro
AU - Nonaka, Kenichi
AU - Masuma, Rokuro
AU - Takizawa, Mami
AU - Nakashima, Takuji
AU - Tokiwa, Toshiyuki
AU - Shiomi, Kazuro
AU - Ōmura, Satoshi
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.
PY - 2021/6
Y1 - 2021/6
N2 - An anti-mannheimiosis agent, aldsulfin, was isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, together with a known compound, lasiodipline C, using bioassay-guided fractionation. Spectroscopic analysis of aldsulfin, using NMR, mass spectrometry, and CD analyses revealed it to be an epithiodiketopiperazine with an unstable and unusual hemithioaminal moiety. Aldsulfin showed antibacterial activity against Mannheimia haemolytica and Pasteurella multocida.
AB - An anti-mannheimiosis agent, aldsulfin, was isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, together with a known compound, lasiodipline C, using bioassay-guided fractionation. Spectroscopic analysis of aldsulfin, using NMR, mass spectrometry, and CD analyses revealed it to be an epithiodiketopiperazine with an unstable and unusual hemithioaminal moiety. Aldsulfin showed antibacterial activity against Mannheimia haemolytica and Pasteurella multocida.
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U2 - 10.1038/s41429-021-00411-8
DO - 10.1038/s41429-021-00411-8
M3 - Article
C2 - 33654250
AN - SCOPUS:85102087596
SN - 0021-8820
VL - 74
SP - 363
EP - 369
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 6
ER -