@article{ce0ff82f808b49da95becac10ee05023,
title = "Alkyldihydropyrones, new polyketides synthesized by a type III polyketide synthase from Streptomyces reveromyceticus",
abstract = "Genome sequencing allows a rapid and efficient identification of novel catalysts that produce novel secondary metabolites. Here we describe the catalytic properties of dihydropyrone synthase A (DpyA), a novel type III polyketide synthase encoded in a linear plasmid of Streptomyces reveromyceticus. Heterologous expression of dpyA led to the accumulation of alkyldihydropyrones A (1), B (2), C (3) and D (4), which are novel dihydropyran compounds that exhibit weak cytotoxicity against the leukemia cell line HL-60. DpyA catalyzes the condensation of β-hydroxyl acid thioester and methylmalonyl-CoA to yield a triketide intermediate that then undergoes lactonization of a secondary alcohol and a thioester to give alkyldihydropyrone.",
author = "Teruki Aizawa and Kim, {Seung Young} and Shunji Takahashi and Masahiko Koshita and Mioka Tani and Yushi Futamura and Hiroyuki Osada and Nobutaka Funa",
note = "Funding Information: We are grateful to Professor MJ Bibb for providing us S. coelicolor M1146. We are also grateful to Professor E Takano for providing us expression vectors pIJ6021 and pIJ4123. This work was, in part, supported by a Grant-in-Aid for Scientific Research on Innovative Areas (23108521) from the Ministry of Education, Culture, Sports, Science and Technology, the Naito Foundation and the Uehara Memorial Foundation. Publisher Copyright: {\textcopyright} 2015 Macmillan Publishers Limited.",
year = "2014",
month = dec,
day = "1",
doi = "10.1038/ja.2014.80",
language = "English",
volume = "67",
pages = "819--823",
journal = "Journal of Antibiotics",
issn = "0021-8820",
publisher = "Japan Antibiotics Research Association",
number = "12",
}