@article{07a8157e038741cc96e824254b1acdda,
title = "Ancorinosides B-D, inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), from the marine sponge Penares sollasi Thiele",
abstract = "Ancorinosides B-D were isolated from the marine sponge Penares sollasi Thiele as inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).1 Their structures were elucidated to be tetramic acid glycosides related to ancorinoside A by spectroscopic and chemical methods. Ancorinosides B-D inhibited MT1-MMP with IC50 values of 180-500 μg/mL.",
keywords = "Biologically active compounds, Enzyme inhibitors, Marine metabolites, Sponges",
author = "Masaki Fujita and Yoichi Nakao and Shigeki Matsunaga and Motoharu Seiki and Yoshifumi Itoh and {Van Soest}, {Rob W.M.} and Nobuhiro Fusetani",
note = "Funding Information: We are indebted to the crew of R/V Toyoshio-maru of Hiroshima University for assistance in collection of the sponge samples. This work was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan and Japan Society for the Promotion of Science, {\textquoteleft}Research for the Future Program{\textquoteright} (JSPS-RFTF 96I00301).",
year = "2001",
month = feb,
day = "11",
doi = "10.1016/S0040-4020(00)01128-5",
language = "English",
volume = "57",
pages = "1229--1234",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Ltd",
number = "7",
}
