Anti-tumorigenesis of hollow calcium-phosphate microsphere loaded with anti-angiogenic agent

M. Aizawa*, T. Ohno, N. Kanomata, K. Yano, M. Emoto


研究成果: Article査読

5 被引用数 (Scopus)


We have successfully synthesized hollow biphasic calcium-phosphate microspheres consisting of the β-tricalcium phosphate (β-Ca 3(PO4)2; β-TCP) and calcium-deficient hydroxyapatite (DAp) using an ultrasonic spray-pyrolysis technique. The resulting hollow biphasic microspheres have been applied as a carrier of a drug delivery system (DDS) for medical treatment of cancers. An anti-angiogenic agent, TNP-470 (Takeda), was used as one of drug models. We have performed biological evaluations in vitro and in vivo using the biodegradable calcium-phosphate microsphere loaded with TNP-470. The results of in vitro and in vivo testing indicate that the microspheres loaded with TNP-470 inhibit i) the proliferation of FU-MMT-3 cells as a tumor model and ii) the enlargement of tumor sizes as a model of nude mice injected with FU-MMT-3 cells. The biological evaluations demonstrate that the present microspheres loaded with TNP-470 have an excellent anti-tumorigenesis effect.

ジャーナルKey Engineering Materials
361-363 II
出版ステータスPublished - 2008

ASJC Scopus subject areas

  • 材料科学(全般)
  • 材料力学
  • 機械工学


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