抄録
A series of pentanthrene type heterocyclic compounds were synthesized and evaluated for anxiolytic activities by three kinds of behavioral pharmacological tests. Several compounds showed anxiolytic activities. In particular, s-triazolo[3,4-a]phthalazine (Tri-P) and 3-propyl derivatives of Tri-P(PTP) showed remarkable activities, although the activities were slightly lower than those of diazepam. The results suggested that Tri-P or PTP is a useful lead compound for the development of the antianxietic agents. The relationship between the structure and anxiolytic activity, and the inducing mechanism of the activity was discussed.
本文言語 | English |
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ページ(範囲) | 400-405 |
ページ数 | 6 |
ジャーナル | Yakugaku Zasshi |
巻 | 113 |
号 | 5 |
DOI | |
出版ステータス | Published - 1993 |
外部発表 | はい |
ASJC Scopus subject areas
- 薬理学
- 薬科学