Asymmetric and highly stereoselective synthesis of the def-ring moiety of (-)-FR182877 and its derivative inducing mitotic arrest

Yu Kobayakawa; Yusuke Mori; Hideki Okajima; Yasuhiko Terada; Masahisa Nakada

doi:10.1021/ol300615w

Asymmetric and highly stereoselective synthesis of the def-ring moiety of (-)-FR182877 and its derivative inducing mitotic arrest

Yu Kobayakawa, Yusuke Mori, Hideki Okajima, Yasuhiko Terada, Masahisa Nakada^*

^*この研究の対応する著者

先進理工学部

研究成果: Article › 査読

9 被引用数 (Scopus)

抄録

The asymmetric and highly stereoselective synthesis of compound 1, which corresponds exactly to the DEF-ring moiety of (-)-FR182877, and the biological activities of its derivatives are described. All derivatives of 1 showed no activity in the tubulin polymerization assay, but one derivative was shown to have the ability to induce mitotic arrest by interfering with microtubule dynamics, and the cellular effects are similar to those of paclitaxel.

本文言語	English
ページ（範囲）	2086-2089
ページ数	4
ジャーナル	Organic Letters
巻	14
号	8
DOI	https://doi.org/10.1021/ol300615w
出版ステータス	Published - 2012 4月 20

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

文献へのアクセス

10.1021/ol300615w

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引用スタイル

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AU - Nakada, Masahisa

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Y1 - 2012/4/20

N2 - The asymmetric and highly stereoselective synthesis of compound 1, which corresponds exactly to the DEF-ring moiety of (-)-FR182877, and the biological activities of its derivatives are described. All derivatives of 1 showed no activity in the tubulin polymerization assay, but one derivative was shown to have the ability to induce mitotic arrest by interfering with microtubule dynamics, and the cellular effects are similar to those of paclitaxel.

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