Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis

Yoichi Nakao; Satoru Yoshida; Shigeki Matsunaga; Nobuaki Shindoh; Yoh Terada; Koji Nagai; Jun K. Yamashita; A. Ganesan; Rob W.M. Van Soest; Nobuhiro Fusetani

doi:10.1002/anie.200602047

Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis

Yoichi Nakao^*, Satoru Yoshida, Shigeki Matsunaga, Nobuaki Shindoh, Yoh Terada, Koji Nagai, Jun K. Yamashita, A. Ganesan, Rob W.M. Van Soest, Nobuhiro Fusetani

^*この研究の対応する著者

研究成果: Article › 査読

111 被引用数 (Scopus)

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A zoom in on azumamides (1): Azumamides A-E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC₅₀ values of 0.045-1.3 μg mL^-1. Their structures were determined on the basis of spectroscopic analysis and chemical degradation. (Chemical Equation Presented)

本文言語	English
ページ（範囲）	7553-7557
ページ数	5
ジャーナル	Angewandte Chemie - International Edition
巻	45
号	45
DOI	https://doi.org/10.1002/anie.200602047
出版ステータス	Published - 2006 11月 20
外部発表	はい

ASJC Scopus subject areas

触媒
化学一般

UN SDG

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abstract = "A zoom in on azumamides (1): Azumamides A-E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC50 values of 0.045-1.3 μg mL-1. Their structures were determined on the basis of spectroscopic analysis and chemical degradation. (Chemical Equation Presented)",

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doi = "10.1002/anie.200602047",

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T2 - Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis

AU - Nakao, Yoichi

AU - Yoshida, Satoru

AU - Matsunaga, Shigeki

AU - Shindoh, Nobuaki

AU - Terada, Yoh

AU - Nagai, Koji

AU - Yamashita, Jun K.

AU - Ganesan, A.

AU - Van Soest, Rob W.M.

AU - Fusetani, Nobuhiro

PY - 2006/11/20

Y1 - 2006/11/20

N2 - A zoom in on azumamides (1): Azumamides A-E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC50 values of 0.045-1.3 μg mL-1. Their structures were determined on the basis of spectroscopic analysis and chemical degradation. (Chemical Equation Presented)

AB - A zoom in on azumamides (1): Azumamides A-E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC50 values of 0.045-1.3 μg mL-1. Their structures were determined on the basis of spectroscopic analysis and chemical degradation. (Chemical Equation Presented)

KW - Angiogenesis

KW - Enzymes

KW - Inhibitors

KW - Natural products

KW - Peptides

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DO - 10.1002/anie.200602047

M3 - Article

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SN - 1433-7851

VL - 45

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EP - 7557

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis

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ASJC Scopus subject areas

UN SDG

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