Biomolecular sensors utilizing waveguide modes excited by evanescent fields

M. Fujimaki*, C. Rockstuhl, X. Wang, K. Awazu, J. Tominaga, T. Ikeda, Y. Koganezawa, Y. Ohki


研究成果: Article査読

15 被引用数 (Scopus)


Properties of evanescent-field-coupled waveguide-mode sensors consisting of a multi-layer structure made of a SiO2 waveguide, a thin metal layer (Au, Cu, W or Ti), and a high refractive index glass substrate illuminated under the Kretschmann configuration have been theoretically and experimentally investigated. In all cases, reflectivity changes attributed to streptavidin combining to biotinyl groups were observed in close spectral vicinity of the waveguide resonances. The sensors with the Au and the Cu layers show superior sensitivity as compared to those with the W and the Ti layers, whereas the W and Ti layers show better thermal and chemical stability. The results indicate that the materials of thin metal layers should be chosen in accordance with the purpose of sensors and/or environment in which the sensors are used.

ジャーナルJournal of Microscopy
出版ステータスPublished - 2008 2月

ASJC Scopus subject areas

  • 病理学および法医学
  • 組織学


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