@article{7c88f062fce547758f22944b9bd8d700,
title = "Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94",
abstract = "We identified the biosynthetic gene cluster for lucilactaene, a cell cycle inhibitor from a filamentous fungus Fusarium sp. RK 97–94. The luc1 knockout strain accumulated demethylated analogs, indicating the involvement of Luc1 methyltransferase in lucilactaene biosynthesis. Lucilactaene showed potent antimalarial activity. Our data suggested that methylation and ether ring formation are essential for its potent antimalarial activity.",
keywords = "Natural products, PKS-NRPS, biological activity, biosynthesis, malaria",
author = "Sho Kato and Takayuki Motoyama and Yushi Futamura and Masakazu Uramoto and Toshihiko Nogawa and Toshiaki Hayashi and Hiroshi Hirota and Akira Tanaka and Naoko Takahashi-Ando and Takashi Kamakura and Hiroyuki Osada",
note = "Funding Information: This study was supported by grants from JSPS KAKENHI Grant Numbers [JP17H06412, JP17K7742, JP17K7784, and JP18H03945]. We would like to thank Ms. Harumi Aono, Dr. Rachael Uson-Lopez, Ms. Emiko Sanada, and Dr. Motoko Uchida for their technical support. Publisher Copyright: {\textcopyright} 2020, {\textcopyright} 2020 Japan Society for Bioscience, Biotechnology, and Agrochemistry.",
year = "2020",
month = jun,
day = "2",
doi = "10.1080/09168451.2020.1725419",
language = "English",
volume = "84",
pages = "1303--1307",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "6",
}