@article{4aaaa9b7cdc644f989fa9e418e1719c2,
title = "Brain activation during whole body cooling in humans studied with functional magnetic resonance imaging",
abstract = "Regional activation of the brain was studied in humans using functional magnetic resonance imaging during whole body cooling that produced thermal comfort/discomfort. Eight normal male subjects lay in a sleeping bag through which air was blown, exposing subjects to cold air (8°C) for 22 min. Each subject scored their degree of thermal comfort and discomfort every min. As the subjects reported more discomfort the blood oxygen level dependent response in the bilateral amygdala increased. There was no activation in the thalamus, somatosensory, cingulate, or insula cortices. This result suggests that the amygdala plays a role in the genesis of thermal discomfort due to cold.",
keywords = "Amygdala, Comfort and discomfort, Functional magnetic resonance imaging, Human, Whole body cooling",
author = "Kazuyuki Kanosue and Norihiro Sadato and Tomohisa Okada and Tamae Yoda and Sadamu Nakai and Kyoko Yoshida and Takayoshi Hosono and Kei Nagashima and Tomoko Yagishita and Osamu Inoue and Kaoru Kobayashi and Yoshiharu Yonekura",
note = "Funding Information: This study was supported in part by by NISSAN SCIENCE FOUNDATION, a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (No. 11557003), and a research grant from {\textquoteleft}Research for the Future{\textquoteright} Program of the Japan Society for the Promotion of Science (JSPS-RFLF97L00203).",
year = "2002",
month = aug,
day = "30",
doi = "10.1016/S0304-3940(02)00621-3",
language = "English",
volume = "329",
pages = "157--160",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",
}