Calicheamicin θ 1I: A Rationally Designed Molecule with Extremely Potent and Selective DNA Cleaving Properties and Apoptosis Inducing Activity

K. C. Nicolaou; T. Li; Masahisa Nakada; Conrad W. Hummel; A. Hiatt; W. Wrasidlo

doi:10.1002/anie.199401831

Calicheamicin θ 1I: A Rationally Designed Molecule with Extremely Potent and Selective DNA Cleaving Properties and Apoptosis Inducing Activity

K. C. Nicolaou^*, T. Li, Masahisa Nakada, Conrad W. Hummel, A. Hiatt, W. Wrasidlo

^*この研究の対応する著者

研究成果: Article › 査読

60 被引用数 (Scopus)

抄録

The attack of a thiolate ion on the trisulfide unit of natural calicheamicin γ I1 (1) activates it to form a diradical, which then attacks DNA. Thioacetate 2 is even more readily activated—under mildly basic conditions caused by OH^‐ ions—and likewise exhibits extremely interesting biological properties. (Figure Presented.)

本文言語	English
ページ（範囲）	183-186
ページ数	4
ジャーナル	Angewandte Chemie International Edition in English
巻	33
号	2
DOI	https://doi.org/10.1002/anie.199401831
出版ステータス	Published - 1994 2月 1
外部発表	はい

ASJC Scopus subject areas

触媒
化学 (全般)

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10.1002/anie.199401831

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