Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata

Masaki Fujita; Yoichi Nakao; Shigeki Matsunaga; Rob W.M. Van Soest; Yoshifumi Itoh; Motoharu Seiki; Nobuhiro Fusetani

doi:10.1021/np020572s

Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata

Masaki Fujita, Yoichi Nakao, Shigeki Matsunaga, Rob W.M. Van Soest, Yoshifumi Itoh, Motoharu Seiki, Nobuhiro Fusetani^*

^*この研究の対応する著者

研究成果: Article › 査読

28 被引用数 (Scopus)

抄録

Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C24 acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC₅₀ of 15.0 μg/mL.

本文言語	English
ページ（範囲）	569-571
ページ数	3
ジャーナル	Journal of Natural Products
巻	66
号	4
DOI	https://doi.org/10.1021/np020572s
出版ステータス	Published - 2003 4月 1
外部発表	はい

ASJC Scopus subject areas

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1021/np020572s

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abstract = "Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C24 acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC50 of 15.0 μg/mL.",

author = "Masaki Fujita and Yoichi Nakao and Shigeki Matsunaga and {Van Soest}, {Rob W.M.} and Yoshifumi Itoh and Motoharu Seiki and Nobuhiro Fusetani",

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T1 - Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata

AU - Fujita, Masaki

AU - Nakao, Yoichi

AU - Matsunaga, Shigeki

AU - Van Soest, Rob W.M.

AU - Itoh, Yoshifumi

AU - Seiki, Motoharu

AU - Fusetani, Nobuhiro

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C24 acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC50 of 15.0 μg/mL.

AB - Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C24 acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC50 of 15.0 μg/mL.

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata

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ASJC Scopus subject areas

UN SDG

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