Carmofur‐Induced Organic Mental Disorders

Summary: Organic mental disorder was observed in a 29‐year‐old female in the prognostic period after the onset of carniofur‐induced lenkoencephalopathy. Symptoms such as euphoria, emotional lability and puerile attitude noted in the patient were diagnosed as organic personality syndrome according to the criteria defined in the DSM‐HI‐R. It is referred to as a frontal lobe syndrome. Brain CT revealed a periventricular low density area in the frontal white matter and moderate dilatation of the lateral ventricles especially at the bilateral anterior horns. Consequently, carmofur‐induced leukoencepha‐lopathy may uncommonly result in organic personality syndrome in the residual state. It may be attributed to the structural damage to the frontal lobe.