@article{2e1d96b96e9d41e29d0dfb8014493821,
title = "Catalytic Dearomative Spirocyclization via Gold Carbene Species Derived from Ynamides: Efficient Synthesis of 2-Azaspiro[4.5]decan-3-ones",
abstract = "An intramolecular catalytic dearomatization of phenols via gold carbene species proceeded to provide 2-azaspiro[4.5]decan-3-ones. The use of NHC ligand and water as a co-solvent was critical for achieving high reactivity. This reaction did not require hazardous diazo compounds as carbene sources and proceeded even under air. The obtained spirocyclic product could be readily transformed into a gabapentin derivative by hydrogenation and deprotection.",
keywords = "carbenes, dearomatization, gold, spirocyclohexadienones, water",
author = "Mamoru Ito and Ryosuke Kawasaki and Kanyiva, {Kyalo Stephen} and Takanori Shibata",
note = "Funding Information: This work was supported by JST, ACT-C, Japan and Waseda University Grant for Special Research Projects. M.I. is grateful to generous support from “Early Bird” grant for young researcher at Waseda Research Institute for Science and Engineering. Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2018",
month = mar,
day = "12",
doi = "10.1002/chem.201800314",
language = "English",
volume = "24",
pages = "3721--3724",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "15",
}