@article{3a4416e946454d6aa99174c448a86c8c,
title = "Cell Mechanosensors and the Possibilities of Using Magnetic Nanoparticles to Study Them and to Modify Cell Fate",
abstract = "The use of magnetic nanoparticles (MNPs) is a promising technique for future advances in biomedical applications. This idea is supported by the availability of MNPs that can target specific cell components, the variety of shapes of MNPs and the possibility of finely controlling the applied magnetic forces. To examine this opportunity, here we review the current developments in the use of MNPs to mechanically stimulate cells and, specifically, the cell mechanotransduction systems. We analyze the cell components that may act as mechanosensors and their effect on cell fate and we focus on the promising possibilities of controlling stem-cell differentiation, inducing cancer-cell death and treating nervous-system diseases.",
keywords = "Cell differentiation, Cytoskeleton, Functionalization, Localized stimulation, Magnetic nanoparticles, Mechanotransduction, Organelle targeting, Rotating magnetic field, Signaling cascade",
author = "Yajing Shen and Yu Cheng and Uyeda, {Taro Q.P.} and Plaza, {Gustavo R.}",
note = "Funding Information: YC thanks the National Science Foundation of China (No. 81571803) the Thousand Talents Plan and Shanghai Pujiang Program (No. 15PJ1407800) for support. GRP and TQPU received a team grant from The Program of High-end Foreign Experts of the State Administration of Foreign Experts Affairs, China. GRP received support from the Ministerio de Econo-m{\'i}a y Competitividad, Spain, througth the project MAT2016-76847-R. Funding Information: YC thanks the National Science Foundation of China (No. 81571803) the Thousand Talents Plan and Shanghai Pujiang Program (No. 15PJ1407800) for support. GRP and TQPU received a team grant from The Program of High-end Foreign Experts of the State Administration of Foreign Experts Affairs, China. GRP received support from the Ministerio de Econom?a y Competitividad, Spain, througth the project MAT2016-76847-R. Publisher Copyright: {\textcopyright} 2017, Biomedical Engineering Society.",
year = "2017",
month = oct,
day = "1",
doi = "10.1007/s10439-017-1884-7",
language = "English",
volume = "45",
pages = "2475--2486",
journal = "Annals of Biomedical Engineering",
issn = "0090-6964",
publisher = "Springer Netherlands",
number = "10",
}
