Cerebral cortex: Symmetric vs: asymmetric cell division

G. Fishell*, C. Hanashima


研究成果: Chapter


The six distinct laminae within the mammalian cerebral cortex contain neurons that exhibit a wide variety of specific physiological properties and synaptic connections. This diversity emerges from a restricted progenitor pool within the embryonic cortical ventricular zone. Individual cortical progenitors produce multiple subtypes over a prolonged period during corticogenesis. This article describes classical studies that suggest that neurogenesis in the cerebral cortex is dependent on asymmetric divisions, where one daughter remains in a progenitor state while the other exits to become a mature neuron. The present understanding of the molecular mechanisms regulating both asymmetric cell division and the sequential production of different neuronal subtypes during development is reviewed. However, as yet only a subset of the factors controlling each of these two events has been identified. This suggests that present genetic approaches will soon significantly extend our understanding of these developmental processes.

ホスト出版物のタイトルEncyclopedia of Neuroscience
出版社Elsevier Ltd
出版ステータスPublished - 2009

ASJC Scopus subject areas

  • 神経科学(全般)


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