TY - JOUR
T1 - Chiba study of mother and children's health (C-MACH)
T2 - Cohort study with omics analyses
AU - On behalf of the Chiba study of Mother and Children's Health group
AU - Sakurai, Kenichi
AU - Miyaso, Hidenobu
AU - Eguchi, Akifumi
AU - Matsuno, Yoshiharu
AU - Yamamoto, Midori
AU - Todaka, Emiko
AU - Fukuoka, Hideoki
AU - Hata, Akira
AU - Mori, Chisato
AU - Sekine, Akihiro
AU - Fujita, Shinsuke
AU - Shimojo, Naoki
AU - Hanazato, Masamichi
AU - Tachibana, Kaori
AU - Nakaoka, Hiroko
AU - Otake, Masae
AU - Suzuki, Norimichi
AU - Watanabe, Masahiro
AU - Osada, Hisao
AU - Shiga, Satomi
AU - Kawanami, Akiko
AU - Takase, Shunya
AU - Koga, Chie
AU - Nakamura, Kiminori
AU - Shinohara, Kazuyuki
AU - Kakeyama, Masaki
AU - Doi, Hirokazu
AU - Sawano, Erika
AU - Tsuji, Toshio
AU - Soh, Zu
AU - Shimatani, Koji
AU - Yamaguchi, Satoru
AU - Onodera, Tsutomu
AU - Yamada., Takuhiro
PY - 2016
Y1 - 2016
N2 - Purpose: Recent epidemiological studies have shown that environmental factors during the fetal period to early childhood might affect the risk of noncommunicable diseases in adulthood. This is referred to as the developmental origins of health and disease (DOHaD) concept. The Chiba study of Mother and Children's Health (C-MACH) is a birth cohort study based on the DOHaD hypothesis and involves multiomics analysis. This study aims to explore the effects of genetic and environmental factors-particularly the fetal environment and postbirth living environment-on children's health, and to identify potential biomarkers for these effects. Participants: The C-MACH consists of three hospitalbased cohorts. The study participants are pregnant women at <13 weeks gestation. Women who underwent an examination in one of the three hospitals received an explanation of the study. The participants consented to completing questionnaire surveys and the collection and storage of biological and house/environmental samples. Participants were provided unique study numbers. All of the data and biological specimens will be stored in the Chiba University Center for Preventive Medical Sciences and Chiba University Center for Preventive Medical Sciences BioBank, respectively. Findings to date: Consent to participate was obtained from 433 women. Of these women, 376 women completed questionnaires in the early gestational period. The mean age was 32.5 (4.4) years. The mean body mass index (BMI) was 21.1 (3.0) kg/m2. Before pregnancy, 72.3% of the women had a BMI of 18.5-24.9 kg/m2. During early pregnancy, 5.0% of the participants smoked. Future plans: Primary outcomes are allergy, obesity, endocrine and metabolic disorders, and developmental disorders. Genome-level, metabolome-level, umbilical cord DNA methylation (epigenome), gut microbiota and environmental chemical exposure variables will be evaluated. We will analyse the relationships between the outcomes and analytical variables.
AB - Purpose: Recent epidemiological studies have shown that environmental factors during the fetal period to early childhood might affect the risk of noncommunicable diseases in adulthood. This is referred to as the developmental origins of health and disease (DOHaD) concept. The Chiba study of Mother and Children's Health (C-MACH) is a birth cohort study based on the DOHaD hypothesis and involves multiomics analysis. This study aims to explore the effects of genetic and environmental factors-particularly the fetal environment and postbirth living environment-on children's health, and to identify potential biomarkers for these effects. Participants: The C-MACH consists of three hospitalbased cohorts. The study participants are pregnant women at <13 weeks gestation. Women who underwent an examination in one of the three hospitals received an explanation of the study. The participants consented to completing questionnaire surveys and the collection and storage of biological and house/environmental samples. Participants were provided unique study numbers. All of the data and biological specimens will be stored in the Chiba University Center for Preventive Medical Sciences and Chiba University Center for Preventive Medical Sciences BioBank, respectively. Findings to date: Consent to participate was obtained from 433 women. Of these women, 376 women completed questionnaires in the early gestational period. The mean age was 32.5 (4.4) years. The mean body mass index (BMI) was 21.1 (3.0) kg/m2. Before pregnancy, 72.3% of the women had a BMI of 18.5-24.9 kg/m2. During early pregnancy, 5.0% of the participants smoked. Future plans: Primary outcomes are allergy, obesity, endocrine and metabolic disorders, and developmental disorders. Genome-level, metabolome-level, umbilical cord DNA methylation (epigenome), gut microbiota and environmental chemical exposure variables will be evaluated. We will analyse the relationships between the outcomes and analytical variables.
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U2 - 10.1136/bmjopen-2015-010531
DO - 10.1136/bmjopen-2015-010531
M3 - Article
C2 - 26826157
AN - SCOPUS:84960158323
SN - 2044-6055
VL - 6
JO - BMJ Open
JF - BMJ Open
IS - 1
M1 - e010531
ER -