Clearance and tissue distribution of functionalized polymeric liposomes from the blood stream of rats

Yoh Ichi Matsushita; Kiyoshi Eshima; Takashi Shindo; Yoshio Yamamoto; Etsuo Hasegawa; Hiroyuki Nishide; Eishun Tsuchida

doi:10.1016/0005-2736(87)90269-0

Clearance and tissue distribution of functionalized polymeric liposomes from the blood stream of rats

Yoh Ichi Matsushita, Kiyoshi Eshima, Takashi Shindo, Yoshio Yamamoto, Etsuo Hasegawa, Hiroyuki Nishide, Eishun Tsuchida^*

^*この研究の対応する著者

理工学術院総合研究所

研究成果: Article › 査読

1 被引用数 (Scopus)

抄録

Polymeric liposomes containing a synthetic porphinato-iron-imidazole complex (hemoglobin or red blood cell model) were labeled by introducing 1,2-di[1-¹⁴C]palmitoyl-sn-glycero-3-phosphocholine into their polymerized bilayers. After intravenous injection into rats, their clearance from a blood stream was measured. The apparent half-life time (50% disappearance time) was about 14 ± 2 h. Their tissue distribution was determined with time by whole autoradiographic measurement.

本文言語	English
ページ（範囲）	166-171
ページ数	6
ジャーナル	BBA - Biomembranes
巻	901
号	1
DOI	https://doi.org/10.1016/0005-2736(87)90269-0
出版ステータス	Published - 1987 7月 10

ASJC Scopus subject areas

生化学
生物理学
細胞生物学
医学（全般）

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10.1016/0005-2736(87)90269-0

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AU - Eshima, Kiyoshi

AU - Shindo, Takashi

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AU - Hasegawa, Etsuo

AU - Nishide, Hiroyuki

AU - Tsuchida, Eishun

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KW - Lipid label

KW - Liposome clearance

KW - Oxygen carrier

KW - Polymeric liposome

KW - Tissue distribution

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Clearance and tissue distribution of functionalized polymeric liposomes from the blood stream of rats

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