TY - JOUR
T1 - Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices
AU - Yoshimura, Shinpei
AU - Okamoto, Yasumasa
AU - Matsunaga, Miki
AU - Onoda, Keiichi
AU - Okada, Go
AU - Kunisato, Yoshihiko
AU - Yoshino, Atsuo
AU - Ueda, Kazutaka
AU - Suzuki, Shin ichi
AU - Yamawaki, Shigeto
N1 - Funding Information:
This work was supported by a Grant-in-Aid for ‘Integrated Research on Depression, Dementia and Development Disorders ( 16dm0107093h0001 )’ and ‘ Development of BMI technologies for clinical application ( 16dm0107050h0003 )’ carried out under the Strategic Research Program for Brain Sciences by AMED, the Brain Mapping by Integrated Neurotechnologies for Disease Studies ( 16dm0207012h0002 ) by AMED , and KAKENHI (Grant numbers 26461748 and 25780413 ) from the JSPS .
Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2017/1/15
Y1 - 2017/1/15
N2 - Background Depression is characterized by negative self-cognition. Our previous study (Yoshimura et al. 2014) revealed changes in brain activity after cognitive behavioral therapy (CBT) for depression, but changes in functional connectivity were not assessed. Method This study included 29 depressive patients and 15 healthy control participants. Functional Magnetic Resonance Imaging was used to investigate possible CBT-related functional connectivity changes associated with negative emotional self-referential processing. Depressed and healthy participants (overlapping with our previous study, Yoshimura et al. 2014) were included. We defined a seed region (medial prefrontal cortex) and coupled region (ACC) based on our previous study, and we examined changes in MPFC-ACC functional connectivity from pretreatment to posttreatment. Results CBT was associated with reduced functional connectivity between the MPFC and ACC. Symptom change with CBT was positively correlated with change in MPFC-ACC functional connectivity. Limitations Patients received pharmacotherapy including antidepressant. The present sample size was quite small and more study is needed. Statistical threshold in fMRI analysis was relatively liberal. Conclusions CBT for depression may disrupt MPFC-ACC connectivity, with associated improvements in depressive symptoms and dysfunctional cognition.
AB - Background Depression is characterized by negative self-cognition. Our previous study (Yoshimura et al. 2014) revealed changes in brain activity after cognitive behavioral therapy (CBT) for depression, but changes in functional connectivity were not assessed. Method This study included 29 depressive patients and 15 healthy control participants. Functional Magnetic Resonance Imaging was used to investigate possible CBT-related functional connectivity changes associated with negative emotional self-referential processing. Depressed and healthy participants (overlapping with our previous study, Yoshimura et al. 2014) were included. We defined a seed region (medial prefrontal cortex) and coupled region (ACC) based on our previous study, and we examined changes in MPFC-ACC functional connectivity from pretreatment to posttreatment. Results CBT was associated with reduced functional connectivity between the MPFC and ACC. Symptom change with CBT was positively correlated with change in MPFC-ACC functional connectivity. Limitations Patients received pharmacotherapy including antidepressant. The present sample size was quite small and more study is needed. Statistical threshold in fMRI analysis was relatively liberal. Conclusions CBT for depression may disrupt MPFC-ACC connectivity, with associated improvements in depressive symptoms and dysfunctional cognition.
KW - Cognitive behavioral therapy
KW - Depression
KW - FMRI
KW - Functional connectivity
KW - Self
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U2 - 10.1016/j.jad.2016.10.017
DO - 10.1016/j.jad.2016.10.017
M3 - Article
C2 - 27810274
AN - SCOPUS:85003498770
SN - 0165-0327
VL - 208
SP - 610
EP - 614
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -
