TY - JOUR
T1 - Collagen-like cell-penetrating peptides
AU - Yamazaki, Chisato M.
AU - Nakase, Ikuhiko
AU - Endo, Hiroyuki
AU - Kishimoto, Saya
AU - Mashiyama, Yoshihiro
AU - Masuda, Ryo
AU - Futaki, Shiroh
AU - Koide, Takaki
PY - 2013/5/17
Y1 - 2013/5/17
N2 - Arginine-rich heterotrimeric collagen-like peptides were prepared, and their cellular uptake efficiency was evaluated. The spatial arrangement of the Arg residues (blue in picture) on the triple-helix surface significantly affected the efficacy of the cellular uptake. The collagen-like triple-helical conformation provides these cell-penetrating peptides with a high resistance to proteases. O=L-4-hydroxyproline.
AB - Arginine-rich heterotrimeric collagen-like peptides were prepared, and their cellular uptake efficiency was evaluated. The spatial arrangement of the Arg residues (blue in picture) on the triple-helix surface significantly affected the efficacy of the cellular uptake. The collagen-like triple-helical conformation provides these cell-penetrating peptides with a high resistance to proteases. O=L-4-hydroxyproline.
KW - cell-penetrating peptides
KW - cellular uptake
KW - collagen
KW - peptides
KW - protein transduction
UR - http://www.scopus.com/inward/record.url?scp=84877717394&partnerID=8YFLogxK
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U2 - 10.1002/anie.201301266
DO - 10.1002/anie.201301266
M3 - Article
C2 - 23592529
AN - SCOPUS:84877717394
SN - 1433-7851
VL - 52
SP - 5497
EP - 5500
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 21
ER -