抄録
Centromeres are epigenetically marked by the assembly of nucleosomes containing the centromere-specific histone H3 variant, CENP-A (CENP-A nucleosome) and their inheritance is probably dictated by the architecture of the centromeric nucleosome. We previously determined the crystal structure of the human CENP-A nucleosome. CENP-A forms a histone octamer containing two each of histones H2A, H2B, H4 and CENP-A and the DNA is left-handedly wrapped around the histone octamer, as in canonical nucleosomes containing histone H3. In the CENP-A nucleosome structure, 13 base pairs of the DNA ends are detached from the histone surface and two CENP-A regions, the aN helix and loop 1, adopt different structures from those in the H3 nucleosome. In this Extra View article, we provide a detailed structural comparison between CENP-A and H3 in nucleosomes and describe their distinctions and similarities.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 6-11 |
| ページ数 | 6 |
| ジャーナル | Nucleus |
| 巻 | 3 |
| 号 | 1 |
| DOI | |
| 出版ステータス | Published - 2012 1月 |
ASJC Scopus subject areas
- 細胞生物学