TY - JOUR
T1 - Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA
AU - Shirai, Mutsunori
AU - Hirakawa, Hideki
AU - Kimoto, Mitsuaki
AU - Tabuchi, Mitsuaki
AU - Kishi, Fumio
AU - Ouchi, Kazunobu
AU - Shiba, Tadayoshi
AU - Ishii, Kazuo
AU - Hattori, Masahira
AU - Kuhara, Satoru
AU - Nakazawa, Teruko
PY - 2000/6/15
Y1 - 2000/6/15
N2 - Chlamydia pneumoniae is a widespread pathogen of humans causing pneumonia and bronchitis. There are many reports of an association between C. pneumoniae infection and atherosclerosis. We determined the whole genome sequence of C. pneumoniae strain J138 isolated in Japan in 1994 and compared it with the sequence of strain CWL029 isolated in the USA before 1987. The J138 circular chromosome consists of 1,226,565 nt (40.7% G + C) with 1072 likely protein-coding genes that is 3665 nt shorter than the CWL029 genome. Plasmids, phage- or transposon-like sequences were not identified. The overall genomic organization, gene order and predicted proteomes of the two strains are very similar, suggesting a high level of structural and functional conservation between the two unrelated isolates. The most conspicuous differences in the J138 genome relative to the CWL029 genome are the absence of five DNA segments, ranging in size from 89 to 1649 nt, and the presence of three DNA segments, ranging from 27 to 84 nt. The complex organization of these 'different zones' may be attributable to a unique system of recombination.
AB - Chlamydia pneumoniae is a widespread pathogen of humans causing pneumonia and bronchitis. There are many reports of an association between C. pneumoniae infection and atherosclerosis. We determined the whole genome sequence of C. pneumoniae strain J138 isolated in Japan in 1994 and compared it with the sequence of strain CWL029 isolated in the USA before 1987. The J138 circular chromosome consists of 1,226,565 nt (40.7% G + C) with 1072 likely protein-coding genes that is 3665 nt shorter than the CWL029 genome. Plasmids, phage- or transposon-like sequences were not identified. The overall genomic organization, gene order and predicted proteomes of the two strains are very similar, suggesting a high level of structural and functional conservation between the two unrelated isolates. The most conspicuous differences in the J138 genome relative to the CWL029 genome are the absence of five DNA segments, ranging in size from 89 to 1649 nt, and the presence of three DNA segments, ranging from 27 to 84 nt. The complex organization of these 'different zones' may be attributable to a unique system of recombination.
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M3 - Article
C2 - 10871362
AN - SCOPUS:0034659939
SN - 0305-1048
VL - 28
SP - 2311
EP - 2314
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - 12
ER -