Concise synthesis of reduced propionates by stereoselective reductions combined with the Kobayashi reaction

Tatsuya Nakamura; Mio Harachi; Takaaki Kano; Yuki Mukaeda; Seijiro Hosokawa

doi:10.1021/ol401406m

Concise synthesis of reduced propionates by stereoselective reductions combined with the Kobayashi reaction

Tatsuya Nakamura, Mio Harachi, Takaaki Kano, Yuki Mukaeda, Seijiro Hosokawa^*

^*この研究の対応する著者

先進理工学部

研究成果: Article › 査読

20 被引用数 (Scopus)

抄録

A concise and straightforward synthesis of 2,4,6-trimethyloctanoates was established by using the sequence of the vinylogous Mukaiyama aldol reaction and regio- and stereoselective reduction reactions. All isomers were obtained selectively in a few steps. The short step synthesis of septoriamycin A, an antimalarial and antileishmanial agent, has been achieved by this methodology.

本文言語	English
ページ（範囲）	3170-3173
ページ数	4
ジャーナル	Organic Letters
巻	15
号	12
DOI	https://doi.org/10.1021/ol401406m
出版ステータス	Published - 2013 6月 21

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1021/ol401406m

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AU - Mukaeda, Yuki

AU - Hosokawa, Seijiro

PY - 2013/6/21

Y1 - 2013/6/21

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AB - A concise and straightforward synthesis of 2,4,6-trimethyloctanoates was established by using the sequence of the vinylogous Mukaiyama aldol reaction and regio- and stereoselective reduction reactions. All isomers were obtained selectively in a few steps. The short step synthesis of septoriamycin A, an antimalarial and antileishmanial agent, has been achieved by this methodology.

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Concise synthesis of reduced propionates by stereoselective reductions combined with the Kobayashi reaction

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