Construction and analysis of a human-chimpanzee comparative clone map

Asao Fujiyama; Hidemi Watanabe; Atsushi Toyoda; Todd D. Taylor; Takehiko Itoh; Shih Feng Tsai; Hong Seog Park; Marie Laure Yaspo; Hans Lehrach; Zhu Chen; Gang Fu; Naruya Saitou; Kazutoyo Osoegawa; Pieter J. De Jong; Yumiko Suto; Masahira Hattori; Yoshiyuki Sakaki

doi:10.1126/science.1065199

Construction and analysis of a human-chimpanzee comparative clone map

Asao Fujiyama^*, Hidemi Watanabe, Atsushi Toyoda, Todd D. Taylor, Takehiko Itoh, Shih Feng Tsai, Hong Seog Park, Marie Laure Yaspo, Hans Lehrach, Zhu Chen, Gang Fu, Naruya Saitou, Kazutoyo Osoegawa, Pieter J. De Jong, Yumiko Suto, Masahira Hattori, Yoshiyuki Sakaki

^*この研究の対応する著者

研究成果: Article › 査読

201 被引用数 (Scopus)

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The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.

本文言語	English
ページ（範囲）	131-134
ページ数	4
ジャーナル	Science
巻	295
号	5552
DOI	https://doi.org/10.1126/science.1065199
出版ステータス	Published - 2002 1月 4
外部発表	はい

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10.1126/science.1065199

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AU - Watanabe, Hidemi

AU - Toyoda, Atsushi

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AU - Itoh, Takehiko

AU - Tsai, Shih Feng

AU - Park, Hong Seog

AU - Yaspo, Marie Laure

AU - Lehrach, Hans

AU - Chen, Zhu

AU - Fu, Gang

AU - Saitou, Naruya

AU - Osoegawa, Kazutoyo

AU - De Jong, Pieter J.

AU - Suto, Yumiko

AU - Hattori, Masahira

AU - Sakaki, Yoshiyuki

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Construction and analysis of a human-chimpanzee comparative clone map

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