Control of pressure-driven microdroplet formation and optimum encapsulation in microfluidic system

Mathias Girault, Akihiro Hattori, Hyonchol Kim, Kenji Matsuura, Masao Odaka, Hideyuki Terazono, Kenji Yasuda*


研究成果: Chapter


Formation of stable micro-droplets in multiphase flow is an important step to perform numerous microfluidic applications such as sorting experiments. We herein investigate the conditions of formation of stable micro-droplets using a flow focusing microfluidic device. Two single phases and four different multiphase flow regimes were observed depending on the pressures of fluids. By tuning sample stream pressure against fixed lower oil stream pressure, stable droplet regime can create microenvironment with a diameter ranged from 30 μm to 140 μm. Results obtained show that the formation of strictly size controlled droplets can encapsulate single cell-sized bead into droplet. Moreover, the limit between unstable and stable droplet regimes was the most suitable to efficiently encapsulate cell-sized bead in droplet sorting application. This limit can be precisely monitored by using the change of the droplet speed found at the threshold between these two regimes.

ホスト出版物のタイトルOceanography Challenges to Future Earth
ホスト出版物のサブタイトルHuman and Natural Impacts on our Seas
出版社Springer International Publishing
出版ステータスPublished - 2019 2月 15

ASJC Scopus subject areas

  • 地球惑星科学(全般)
  • 農業および生物科学(全般)
  • 環境科学(全般)
  • 工学(全般)


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