Control theoretic views on circadian rhythms

T. Takeuchi*, T. Hinohara, K. Uchida, S. Shibata


研究成果: Paper査読


Circadian rhythms, which are observed in most of living things, e.g. bacteria, fungi, plants, and animals, are self-sustained oscillations with about 24 hours period, and have the following properties: The first property is that the oscillation is entrained by light/dark cycles; the second one is that the oscillation, especially the period of the oscillation, is robust against changes of environment. In this paper, we investigate these two properties from control theoretic viewpoints. First, considering light/dark cycle as periodic control input, we try to explain how periodic control inputs can entrain one self-sustained circadian oscillator described by a core molecular model for Drosophila by Goldbeter (1995). Second, for structural understanding of robustness of circadian rhythms, we propose an evaluation method of the robustness based on period sensitivity, and try to design some rate parameters, which are regarded as control parameters, based on some optimizations using a robustness measure, when a rate parameter is moved to outside of normal area by environmental changes.

出版ステータスPublished - 2006 12月 1
イベント2006 IEEE International Conference on Control Applications, CCA 2006 - Munich, Germany
継続期間: 2006 10月 42006 10月 6


Conference2006 IEEE International Conference on Control Applications, CCA 2006

ASJC Scopus subject areas

  • 制御およびシステム工学
  • コンピュータ サイエンスの応用
  • 数学 (全般)


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