Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata

Shin Taro Ishigami; Yasuyuki Goto; Noboru Inoue; Shin Ichiro Kawazu; Yoshitsugu Matsumoto; Yukimitsu Imahara; Moto Tarumi; Hiromi Nakai; Nobuhiro Fusetani; Yoichi Nakao

doi:10.1021/jo302109g

Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata

Shin Taro Ishigami, Yasuyuki Goto, Noboru Inoue, Shin Ichiro Kawazu, Yoshitsugu Matsumoto, Yukimitsu Imahara, Moto Tarumi, Hiromi Nakai, Nobuhiro Fusetani, Yoichi Nakao^*

^*この研究の対応する著者

先進理工学部

研究成果: Article › 査読

26 被引用数 (Scopus)

抄録

A new xenicane diterpenoid, cristaxenicin A (1), has been isolated from the deep sea gorgonian Acanthoprimnoa cristata. The structure of 1 was elucidated on the basis of spectral analysis including NMR and MS. The absolute configuration of 1 was determined on the basis of quantum chemical calculation of CD spectra. Cristaxenicin A (1) showed antiprotozoal activities against Leishmania amazonensis and Trypanosoma congolense with IC₅₀ values of 0.088 and 0.25 μM, respectively.

本文言語	English
ページ（範囲）	10962-10966
ページ数	5
ジャーナル	Journal of Organic Chemistry
巻	77
号	23
DOI	https://doi.org/10.1021/jo302109g
出版ステータス	Published - 2012 12月 7

ASJC Scopus subject areas

有機化学

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10.1021/jo302109g

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abstract = "A new xenicane diterpenoid, cristaxenicin A (1), has been isolated from the deep sea gorgonian Acanthoprimnoa cristata. The structure of 1 was elucidated on the basis of spectral analysis including NMR and MS. The absolute configuration of 1 was determined on the basis of quantum chemical calculation of CD spectra. Cristaxenicin A (1) showed antiprotozoal activities against Leishmania amazonensis and Trypanosoma congolense with IC50 values of 0.088 and 0.25 μM, respectively.",

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AU - Ishigami, Shin Taro

AU - Goto, Yasuyuki

AU - Inoue, Noboru

AU - Kawazu, Shin Ichiro

AU - Matsumoto, Yoshitsugu

AU - Imahara, Yukimitsu

AU - Tarumi, Moto

AU - Nakai, Hiromi

AU - Fusetani, Nobuhiro

AU - Nakao, Yoichi

PY - 2012/12/7

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AB - A new xenicane diterpenoid, cristaxenicin A (1), has been isolated from the deep sea gorgonian Acanthoprimnoa cristata. The structure of 1 was elucidated on the basis of spectral analysis including NMR and MS. The absolute configuration of 1 was determined on the basis of quantum chemical calculation of CD spectra. Cristaxenicin A (1) showed antiprotozoal activities against Leishmania amazonensis and Trypanosoma congolense with IC50 values of 0.088 and 0.25 μM, respectively.

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Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata

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