TY - JOUR
T1 - Decrease of sexual receptivity by prolylendopeptidase inhibitor in female rats
AU - Oosuka, Izumi
AU - Tanaka, Yoshiaki
AU - Miura, Naoyoshi
AU - Yamanouchi, Korehito
PY - 2000
Y1 - 2000
N2 - The effects of a prolylendopeptidase inhibitor, 1-[3-(2-indanylanylacetyl)-L-thioprolyl]pyrrolidine (Z-321), on lordosis behavior were investigated in estrogen and progesterone-treated ovariectomized rats. Females were orally administered 100, 200 or 300 mg/kg Z-321 or the vehicle (control). The mean lordosis quotient in the rats given 300 mg/kg Z-321 was lower than that in control group, but that in rats given 100 or 200 mg/kg Z-321 was not lower. Thus, Z-321 suppressed lordosis in estrogen and progesterone-treated ovariectomized rats. Peptide neurotransmitters, especially those containing proline, are thought to be involved in the inhibitory mechanisms for lordosis behavior.
AB - The effects of a prolylendopeptidase inhibitor, 1-[3-(2-indanylanylacetyl)-L-thioprolyl]pyrrolidine (Z-321), on lordosis behavior were investigated in estrogen and progesterone-treated ovariectomized rats. Females were orally administered 100, 200 or 300 mg/kg Z-321 or the vehicle (control). The mean lordosis quotient in the rats given 300 mg/kg Z-321 was lower than that in control group, but that in rats given 100 or 200 mg/kg Z-321 was not lower. Thus, Z-321 suppressed lordosis in estrogen and progesterone-treated ovariectomized rats. Peptide neurotransmitters, especially those containing proline, are thought to be involved in the inhibitory mechanisms for lordosis behavior.
KW - Lordosis
KW - Peptide neurotransmitter
KW - Prolylendopeptidase inhibitor
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U2 - 10.1254/jjp.83.82
DO - 10.1254/jjp.83.82
M3 - Article
C2 - 10887944
AN - SCOPUS:0034076994
SN - 0021-5198
VL - 83
SP - 82
EP - 85
JO - Japanese Journal of Pharmacology
JF - Japanese Journal of Pharmacology
IS - 1
ER -