TY - JOUR
T1 - Decreased response inhibition in middle-aged male patients with type 2 diabetes
AU - Ishizawa, Kaya T.
AU - Kumano, Hiroaki
AU - Sato, Atsushi
AU - Sakura, Hiroshi
AU - Iwamoto, Yasuhiko
N1 - Funding Information:
This study was partly supported by a grant-in-aid from the Ministry of Health, Labour and Welfare of Japan awarded to the second author (HK). The authors are grateful to the staff of the Department of Psychosomatic Medicine, The University of Tokyo. We also thank the clinical staff of the Diabetes Center, Tokyo Women’s Medical University.
PY - 2010/2/11
Y1 - 2010/2/11
N2 - Background: This study was performed to examine whether patients with type 2 diabetes have cognitive deficits associated with the prefrontal cortex (PFC).Methods: Twenty-seven middle-aged patients with newly diagnosed type 2 diabetes and 27 healthy controls underwent physical measurements and neuropsychological tasks. Response inhibition, reward prediction, and executive function were assessed by the Go/NoGo task, the reversal and extinction tasks, and the Wisconsin Card Sorting Test (WCST). To examine the interactions of being overweight with diabetes on cognitive performance, performance data were analysed by two-way ANCOVA with diabetes and overweight as factors and age as a covariate.Results: Patients with type 2 diabetes showed significantly decreased response inhibition in the Go/NoGo task (discriminability index: P = 0.001). There was an interaction of being overweight with diabetes on reaction time in the Go trials of the Go/NoGo task (P = 0.009). Being overweight was related to retained responses to the presentiment of reward in the extinction task (P = 0.029). The four groups showed normal cognitive performance in the WCST.Conclusions: Our results showed that middle-aged, newly diagnosed and medication-free patients with type 2 diabetes have a particular neuropsychological deficit in inhibitory control of impulsive response, which is an independent effect of diabetes apart from being overweight.
AB - Background: This study was performed to examine whether patients with type 2 diabetes have cognitive deficits associated with the prefrontal cortex (PFC).Methods: Twenty-seven middle-aged patients with newly diagnosed type 2 diabetes and 27 healthy controls underwent physical measurements and neuropsychological tasks. Response inhibition, reward prediction, and executive function were assessed by the Go/NoGo task, the reversal and extinction tasks, and the Wisconsin Card Sorting Test (WCST). To examine the interactions of being overweight with diabetes on cognitive performance, performance data were analysed by two-way ANCOVA with diabetes and overweight as factors and age as a covariate.Results: Patients with type 2 diabetes showed significantly decreased response inhibition in the Go/NoGo task (discriminability index: P = 0.001). There was an interaction of being overweight with diabetes on reaction time in the Go trials of the Go/NoGo task (P = 0.009). Being overweight was related to retained responses to the presentiment of reward in the extinction task (P = 0.029). The four groups showed normal cognitive performance in the WCST.Conclusions: Our results showed that middle-aged, newly diagnosed and medication-free patients with type 2 diabetes have a particular neuropsychological deficit in inhibitory control of impulsive response, which is an independent effect of diabetes apart from being overweight.
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U2 - 10.1186/1751-0759-4-1
DO - 10.1186/1751-0759-4-1
M3 - Article
C2 - 20181219
AN - SCOPUS:77949461267
SN - 1751-0759
VL - 4
JO - BioPsychoSocial Medicine
JF - BioPsychoSocial Medicine
M1 - 1
ER -
