Development of DNA-conjugated microtubules for selective hybridization and transporting of target DNA

Shu Taira; Yong Zhong Du; Yuichi Hiratsuka; Kaoru Konishi; Tai Kubo; Taro Q.P. Uyeda; Noboru Yumoto; Masato Kodaka

Development of DNA-conjugated microtubules for selective hybridization and transporting of target DNA

Shu Taira^*, Yong Zhong Du, Yuichi Hiratsuka, Kaoru Konishi, Tai Kubo, Taro Q.P. Uyeda, Noboru Yumoto, Masato Kodaka

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研究成果: Paper › 査読

抄録

We have created a strategy in which hybridized-target DNA is not only detected but also transported using DNA-microtubules (MTs) conjugates and kinesin motor proteins. This technique is capable of collecting target biomolecules toward one point site. We have confirmed selective hybridization to target fully matched DNA and transport ability of DNA on the kinesin-coated substrate using the present DNA-conjugated MTs. By combining a technique to control the direction of MTs movement, this new system of selective detection and transport of DNA would be explored as a method for enrichment of DNA and DNA-affinity molecules.

本文言語	English
ページ	2326
ページ数	1
出版ステータス	Published - 2005
外部発表	はい
イベント	54th SPSJ Annual Meeting 2005 - Yokohama, Japan 継続期間: 2005 5月 25 → 2005 5月 27

Conference

Conference	54th SPSJ Annual Meeting 2005
国/地域	Japan
City	Yokohama
Period	05/5/25 → 05/5/27

ASJC Scopus subject areas

工学（全般）

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引用スタイル

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title = "Development of DNA-conjugated microtubules for selective hybridization and transporting of target DNA",

abstract = "We have created a strategy in which hybridized-target DNA is not only detected but also transported using DNA-microtubules (MTs) conjugates and kinesin motor proteins. This technique is capable of collecting target biomolecules toward one point site. We have confirmed selective hybridization to target fully matched DNA and transport ability of DNA on the kinesin-coated substrate using the present DNA-conjugated MTs. By combining a technique to control the direction of MTs movement, this new system of selective detection and transport of DNA would be explored as a method for enrichment of DNA and DNA-affinity molecules.",

keywords = "DNA-conjugated microtubule, Motor protein, SNP analysis",

author = "Shu Taira and Du, {Yong Zhong} and Yuichi Hiratsuka and Kaoru Konishi and Tai Kubo and Uyeda, {Taro Q.P.} and Noboru Yumoto and Masato Kodaka",

year = "2005",

language = "English",

pages = "2326",

note = "54th SPSJ Annual Meeting 2005 ; Conference date: 25-05-2005 Through 27-05-2005",

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TY - CONF

T1 - Development of DNA-conjugated microtubules for selective hybridization and transporting of target DNA

AU - Taira, Shu

AU - Du, Yong Zhong

AU - Hiratsuka, Yuichi

AU - Konishi, Kaoru

AU - Kubo, Tai

AU - Uyeda, Taro Q.P.

AU - Yumoto, Noboru

AU - Kodaka, Masato

PY - 2005

Y1 - 2005

N2 - We have created a strategy in which hybridized-target DNA is not only detected but also transported using DNA-microtubules (MTs) conjugates and kinesin motor proteins. This technique is capable of collecting target biomolecules toward one point site. We have confirmed selective hybridization to target fully matched DNA and transport ability of DNA on the kinesin-coated substrate using the present DNA-conjugated MTs. By combining a technique to control the direction of MTs movement, this new system of selective detection and transport of DNA would be explored as a method for enrichment of DNA and DNA-affinity molecules.

AB - We have created a strategy in which hybridized-target DNA is not only detected but also transported using DNA-microtubules (MTs) conjugates and kinesin motor proteins. This technique is capable of collecting target biomolecules toward one point site. We have confirmed selective hybridization to target fully matched DNA and transport ability of DNA on the kinesin-coated substrate using the present DNA-conjugated MTs. By combining a technique to control the direction of MTs movement, this new system of selective detection and transport of DNA would be explored as a method for enrichment of DNA and DNA-affinity molecules.

KW - DNA-conjugated microtubule

KW - Motor protein

KW - SNP analysis

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M3 - Paper

AN - SCOPUS:33645641440

SP - 2326

T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Development of DNA-conjugated microtubules for selective hybridization and transporting of target DNA

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Conference

ASJC Scopus subject areas

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