Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats

Pham Hung; Shihoko Kaku; Shin Ichi Yunoki; Ken Ichi Ohkura; Jiong Yan Gu; Ikuo Ikeda; Michihiro Sugano; Kazunaga Yazawa; Koji Yamada

Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats

Pham Hung, Shihoko Kaku, Shin Ichi Yunoki, Ken Ichi Ohkura, Jiong Yan Gu, Ikuo Ikeda, Michihiro Sugano, Kazunaga Yazawa, Koji Yamada^*

^*この研究の対応する著者

研究成果: Article › 査読

22 被引用数 (Scopus)

抄録

The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB₄, reflecting their lower arachidonic acid level, and a higher amount of LTB₅, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.

本文言語	English
ページ（範囲）	135-140
ページ数	6
ジャーナル	Bioscience, Biotechnology and Biochemistry
巻	63
号	1
出版ステータス	Published - 1999 1月
外部発表	はい

ASJC Scopus subject areas

食品科学
生化学、遺伝学、分子生物学（全般）
生化学
バイオテクノロジー
化学（その他）
応用微生物学とバイオテクノロジー
バイオエンジニアリング

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title = "Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats",

abstract = "The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.",

keywords = "Fatty acid, Fish oil, Histamine, Immunoglobulin, Leukotriene",

author = "Pham Hung and Shihoko Kaku and Yunoki, {Shin Ichi} and Ohkura, {Ken Ichi} and Gu, {Jiong Yan} and Ikuo Ikeda and Michihiro Sugano and Kazunaga Yazawa and Koji Yamada",

year = "1999",

month = jan,

language = "English",

volume = "63",

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AU - Hung, Pham

AU - Kaku, Shihoko

AU - Yunoki, Shin Ichi

AU - Ohkura, Ken Ichi

AU - Gu, Jiong Yan

AU - Ikeda, Ikuo

AU - Sugano, Michihiro

AU - Yazawa, Kazunaga

AU - Yamada, Koji

PY - 1999/1

Y1 - 1999/1

N2 - The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.

AB - The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.

KW - Fatty acid

KW - Fish oil

KW - Histamine

KW - Immunoglobulin

KW - Leukotriene

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C2 - 10052133

AN - SCOPUS:0032610565

SN - 0916-8451

VL - 63

SP - 135

EP - 140

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 1

ER -

Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats

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