Direct partial CH3 termination into carboxyl terminated diamond surface for biosensor

Immobilization is an important process of biosensor application. The simplest functionalize diamond surface was done by attached biomolecule on diamond surface with chemical linker compound modification. Carboxyl treatment is one choice for diamond functionalization. Methane gas was diluted with hydrogen gas for CH3 termination as an initial functionalization of diamond to transform to carboxyl termination. Diamond and biomolecule is a couple of highly functionally collaboration for biosensor even with low coverage for carboxyl terminated. This work shows that low coverage of carboxyl (∼1%) as the great data with high stability for biosensor applications.