Diurnal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts

Teppei Koyama; Shogo Haraguchi; Hubert Vaudry; Kazuyoshi Tsutsui

doi:10.1111/j.1749-6632.2008.03622.x

Diurnal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts

Teppei Koyama, Shogo Haraguchi, Hubert Vaudry, Kazuyoshi Tsutsui^*

^*この研究の対応する著者

研究成果: Conference contribution

10 被引用数 (Scopus)

抄録

We recently identified 7α-hydroxypregnenolone as a novel amphibian neurosteroid stimulating locomotor activity in newts. Because male newts show marked diurnal changes in locomotor activity, we hypothesized that 7α-hydroxypregnenolone may be a key factor for the induction of diurnal changes in locomotor activity in male newts. In this study, we found diurnal changes in 7α-hydroxypregnenolone synthesis in the brain of male newts, which paralleled locomotor activity. Interestingly, the production of 7α-hydroxypregnenolone in the male newt brain increased during the dark phase when locomotor activity of males was high.

本文言語	English
ホスト出版物のタイトル	Annals of the New York Academy of Sciences
ページ	444-447
ページ数	4
巻	1163
DOI	https://doi.org/10.1111/j.1749-6632.2008.03622.x
出版ステータス	Published - 2009 4月

出版物シリーズ

名前	Annals of the New York Academy of Sciences
巻	1163
ISSN（印刷版）	00778923
ISSN（電子版）	17496632

ASJC Scopus subject areas

生化学、遺伝学、分子生物学（全般）

文献へのアクセス

10.1111/j.1749-6632.2008.03622.x

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引用スタイル

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abstract = "We recently identified 7α-hydroxypregnenolone as a novel amphibian neurosteroid stimulating locomotor activity in newts. Because male newts show marked diurnal changes in locomotor activity, we hypothesized that 7α-hydroxypregnenolone may be a key factor for the induction of diurnal changes in locomotor activity in male newts. In this study, we found diurnal changes in 7α-hydroxypregnenolone synthesis in the brain of male newts, which paralleled locomotor activity. Interestingly, the production of 7α-hydroxypregnenolone in the male newt brain increased during the dark phase when locomotor activity of males was high.",

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AU - Vaudry, Hubert

AU - Tsutsui, Kazuyoshi

PY - 2009/4

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N2 - We recently identified 7α-hydroxypregnenolone as a novel amphibian neurosteroid stimulating locomotor activity in newts. Because male newts show marked diurnal changes in locomotor activity, we hypothesized that 7α-hydroxypregnenolone may be a key factor for the induction of diurnal changes in locomotor activity in male newts. In this study, we found diurnal changes in 7α-hydroxypregnenolone synthesis in the brain of male newts, which paralleled locomotor activity. Interestingly, the production of 7α-hydroxypregnenolone in the male newt brain increased during the dark phase when locomotor activity of males was high.

AB - We recently identified 7α-hydroxypregnenolone as a novel amphibian neurosteroid stimulating locomotor activity in newts. Because male newts show marked diurnal changes in locomotor activity, we hypothesized that 7α-hydroxypregnenolone may be a key factor for the induction of diurnal changes in locomotor activity in male newts. In this study, we found diurnal changes in 7α-hydroxypregnenolone synthesis in the brain of male newts, which paralleled locomotor activity. Interestingly, the production of 7α-hydroxypregnenolone in the male newt brain increased during the dark phase when locomotor activity of males was high.

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KW - Diurnal changes

KW - Locomotor activity

KW - Neurosteroids

KW - Newts

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DO - 10.1111/j.1749-6632.2008.03622.x

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T3 - Annals of the New York Academy of Sciences

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BT - Annals of the New York Academy of Sciences

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Diurnal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts

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