@article{5184048f13d34d9e90b63625f004549a,
title = "Effect of Alkynyl Group on Reactivity in Photoaffinity Labeling with 2-Thienyl-Substituted α-Ketoamide",
abstract = "Minimalist photo-reactive probes, which consist of a photo-reactive group and a tag for detection of target proteins, are useful tools in chemical biology. Although several diazirine-based and aryl azide-based minimalist probes are available, no keto-based minimalist probe has yet been reported. Here we describe minimalist probes based on a 2-thienyl-substituted α-ketoamide bearing an alkyne group on the thiophene ring. The 3-alkyne probe showed the highest photo-affinity labeling efficiency.",
keywords = "alkynes, photo-affinity labeling, spin density, thiophenes, α-ketoamides",
author = "Takahiro Moriyama and Daiki Mizukami and Makoto Yoritate and Kazuteru Usui and Daisuke Takahashi and Eisuke Ota and Mikiko Sodeoka and Tadashi Ueda and Satoru Karasawa and Go Hirai",
note = "Funding Information: This study was partially supported by PRIME and the Platform Project for Supporting Drug Discovery and Life Science Research (BINDS) from the Japan Agency for Medical Research and Development, AMED, the JSPS KAKENHI (grants no. 21K19053, 21H02070, and 20K15957), and the Sumitomo Foundation. Publisher Copyright: {\textcopyright} 2022 Wiley-VCH GmbH.",
year = "2022",
month = feb,
day = "19",
doi = "10.1002/chem.202103925",
language = "English",
volume = "28",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "11",
}