TY - JOUR
T1 - Effect of magnetite nanoparticles on living rate of MCF-7 human breast cancer cells
AU - Baba, Daisuke
AU - Seiko, Yasuhiro
AU - Nakanishi, Takuya
AU - Zhang, Hong
AU - Arakaki, Atsushi
AU - Matsunaga, Tadashi
AU - Osaka, Tetsuya
N1 - Funding Information:
This work was financially supported by a Grant-in-Aid for Specially Promoted Research, “Establishment of Electrochemical Device Engineering,” and the Global COE program, “Practical Chemical Wisdom,” from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan . This work was partly carried out at the Consolidated Research Institute for Advanced Science and Medical Care, Waseda University (ASMeW).
PY - 2012/6/15
Y1 - 2012/6/15
N2 - Superparamagnetic and ferromagnetic magnetite nanoparticles, with diameters of approximately 13 and 44. nm, respectively, were synthesized and their uptake amount and heating efficiency were evaluated for application to magnetic hyperthermia. Both nanoparticles had almost the same zeta-potential (+10.2. mV) and hydrodynamic size (~1μm) and there was no significant difference in their uptake amount 18. h after they were added to the medium. After internalization, the ferromagnetic nanoparticles incorporated in human breast cancer cells (MCF-7) showed a higher heating efficiency than the superparamagnetic nanoparticles when an external magnetic field (4. kW, 250. kHz) high enough to produce heat by hysteresis loss was applied, followed by cellular death of MCF-7 with high ferromagnetic nanoparticle content.
AB - Superparamagnetic and ferromagnetic magnetite nanoparticles, with diameters of approximately 13 and 44. nm, respectively, were synthesized and their uptake amount and heating efficiency were evaluated for application to magnetic hyperthermia. Both nanoparticles had almost the same zeta-potential (+10.2. mV) and hydrodynamic size (~1μm) and there was no significant difference in their uptake amount 18. h after they were added to the medium. After internalization, the ferromagnetic nanoparticles incorporated in human breast cancer cells (MCF-7) showed a higher heating efficiency than the superparamagnetic nanoparticles when an external magnetic field (4. kW, 250. kHz) high enough to produce heat by hysteresis loss was applied, followed by cellular death of MCF-7 with high ferromagnetic nanoparticle content.
KW - Cancer
KW - Magnetic hyperthermia
KW - Magnetism
KW - Magnetite nanoparticles
KW - Uptake
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U2 - 10.1016/j.colsurfb.2012.03.008
DO - 10.1016/j.colsurfb.2012.03.008
M3 - Article
C2 - 22486944
AN - SCOPUS:84860562645
SN - 0927-7765
VL - 95
SP - 254
EP - 257
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
ER -
