TY - JOUR
T1 - Effects and serum levels of thrombopoietin in a case of chronic thrombocytopenia with achondroplasia
AU - Ishiguro, Akira
AU - Nakahata, Tatsutoshi
AU - Muraoka, Kenji
AU - Tomoyuki Tahara, Tahara
AU - Miyazaki, Hiroshi
AU - Kato, Takashi
AU - Inaba, Yuji
AU - Shimbo, Toshikazu
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1997/7
Y1 - 1997/7
N2 - Thrombopoietin (TPO), produced mainly in the liver, is a major regulator of platelet production. Serum TPO levels are generally increased in thrombocytopenia. We report a case of a 12-year-old boy with chronic severe thrombocytopenia, achondroplasia and nephritis. Severe chronic thrombocytopenia was found at 9 months of age. It was resistant to any treatment. Studies on megakaryocytic colonies in vitro revealed that the marrow cells responded well to TPO and no plasma inhibitor was found. Although hepatic function test results were normal, serum TPO levels in the patient (0.94 fmol/ml) were consistent with those in age-matched children (0.49 1.75 fmol/ml). Chronic thrombocytopenia requires individual evaluation before clinical trials with TPO.
AB - Thrombopoietin (TPO), produced mainly in the liver, is a major regulator of platelet production. Serum TPO levels are generally increased in thrombocytopenia. We report a case of a 12-year-old boy with chronic severe thrombocytopenia, achondroplasia and nephritis. Severe chronic thrombocytopenia was found at 9 months of age. It was resistant to any treatment. Studies on megakaryocytic colonies in vitro revealed that the marrow cells responded well to TPO and no plasma inhibitor was found. Although hepatic function test results were normal, serum TPO levels in the patient (0.94 fmol/ml) were consistent with those in age-matched children (0.49 1.75 fmol/ml). Chronic thrombocytopenia requires individual evaluation before clinical trials with TPO.
KW - Achondroplasia
KW - Megakaryocyte
KW - Platelet
KW - Thrombocytopenia
KW - Thrombopoietin
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U2 - 10.1016/s0925-5710(97)00587-2
DO - 10.1016/s0925-5710(97)00587-2
M3 - Article
C2 - 9220665
AN - SCOPUS:0031194134
SN - 0925-5710
VL - 66
SP - 99
EP - 102
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 1
ER -