@article{5a03e1d212814c9ab0a2993f37e4a74f,
title = "Enantioselective Formal C−H Conjugate Addition of Acetanilides to β-Substituted Acrylates by Chiral Iridium Catalysts",
abstract = "The Ir-catalyzed enantioselective reaction of substituted acetanilides with β-substituted α,β-unsaturated esters provided chiral 3,3-disubstituted propanoates in high yield with good-to-excellent enantiomeric excess (up to 99 % ee). This transformation, initiated by sp2C−H bond activation, is the first example of enantioselective formal C−H conjugate addition to β-substituted α,β-unsaturated carbonyl compounds. The starting materials are commercially available and/or readily accessible.",
keywords = "C−H alkylation, acetanilides, conjugate addition, enantioselective, iridium",
author = "Takanori Shibata and Masamichi Michino and Hisaki Kurita and Tahara, {Yu Ki} and Kanyiva, {Kyalo Stephen}",
note = "Funding Information: This work was supported by JST, ACT-C, Japan, and Waseda University Grant for Special Research Projects. We are grateful to Umicore for generous supports in [IrCl(cod)]2supply. Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2017",
month = jan,
day = "1",
doi = "10.1002/chem.201604962",
language = "English",
volume = "23",
pages = "88--91",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "1",
}